Naslov
Differential diagnostic performance of Rose bengal score test in Sjogren's syndrome patients

Autori
Knezović, Igor ; Alajbeg, Ivan ; Karlović, Dalibor ; Pavan, Josip ; Vrkić, Nada ; Bišćan, Ana

Izvornik
Collegium Antropologicum (0350-6134) 35 (2011), 4; 1105-1113

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Rose bengal score; Sjøgren syndrome; focus score; Tear Break-up Time test; ophtalmologic questionnaire

Sažetak
Aim of the study was to evaluate the diagnostic performance of the Rose bengal score test for Sjøgren's syndrome (SS), and to explore differences between other tests and examinations. All participants were examined: unstimulated (UWS) and stimulated (SWS) whole saliva, labial gland biopsy (LGB or focus score), ophthalmologic questionnaire (ocular surface disease indeks OSDI) and objective tests: Schirmer test 1 (Sch.1), Schirmer test 2 (Sch.2), Tear Break-up Time (TBUT) test and Rose bengal score (RBS). Data were analyzed using Mann Whitney U-test, Receiver Operating Characteristic analysis, with specificity and sensitivity calculations and Spearman’s correlation test. ROC curves showed a poor diagnostic performance of TBUT and OSDI. Sch.1, Sch.2 and LGB all exhibited a high diagnostic performance. RBS exhibited the best performance (sensitivity 100, 00 ; specificity 100, 00 ; AUC 1, 000). Study reveals the scarce reliability of TBUT, OSDI and Sch.1, and emphasizes RBS as the test of choice in the SS diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

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