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Pregled bibliografske jedinice broj: 465402

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

Lips, E.H.; Gaborieau, V.; McKay, J.D.; Chabrier, A.; Hung, R.J.; Boffetta, P.; Hashibe, M.; Zaridze, D.; Szeszenia-Dabrowska, N.; Lissowska, J. et al.
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals // International journal of epidemiology, 39 (2010), 2; 563-577 doi:10.1093/ije/dyp288 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 465402 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

Autori
Lips, E.H. ; Gaborieau, V. ; McKay, J.D. ; Chabrier, A. ; Hung, R.J. ; Boffetta, P. ; Hashibe, M. ; Zaridze, D. ; Szeszenia-Dabrowska, N. ; Lissowska, J. ; Rudnai, P. ; Fabianova, E. ; Mates, D. ; Bencko, V. ; Foretova, L. ; Janout, V. ; Field, J.K. ; Liloglou, T. ; Xinarianos, G. ; McLaughlin, J. ; Liu, G. ; Skorpen, F. ; Elvestad, M.B. ; Hveem, K. ; Vatten, L. ; Study, E. ; Benhamou, S. ; Lagiou, P. ; Holcátová, I. ; Merletti, F. ; Kjaerheim, K. ; Agudo, A. ; Castellsagué, X. ; Macfarlane, T.V. ; Barzan, L. ; Canova, C. ; Lowry, R. ; Conway, D.I. ; Znaor, Ariana ; Healy, C. ; Curado, M.P. ; Koifman, S. ; Eluf-Neto, J. ; Matos, E. ; Menezes, A. ; Fernandez, L. ; Metspalu, A. ; Heath, S. ; Lathrop, M. ; Brennan, P.

Izvornik
International journal of epidemiology (0300-5771) 39 (2010), 2; 563-577

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
upper aerodigestive tract cancers; smoking quantity; 15q25 gene variant

Sažetak
Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens. We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a total of 17 300 subjects from five LC studies and four upper aerodigestive tract (UADT) cancer studies. Subjects with one minor allele smoked on average 0.3 cigarettes per day (CPD) more, whereas subjects with the homozygous minor AA genotype smoked on average 1.2 CPD more than subjects with a GG genotype (P < 0.001). The variant was associated with heavy smoking (>20 CPD) [odds ratio (OR) = 1.13, 95% confidence interval (CI) 0.96-1.34, P = 0.13 for heterozygotes and 1.81, 95% CI 1.39-2.35 for homozygotes, P < 0.0001]. The strong association between the variant and LC risk (OR = 1.30, 95% CI 1.23-1.38, P = 1 x 10(-18)), was virtually unchanged after adjusting for this smoking association (smoking adjusted OR = 1.27, 95% CI 1.19-1.35, P = 5 x 10(-13)). Furthermore, we found an association between the variant allele and an earlier age of LC onset (P = 0.02). The association was also noted in UADT cancers (OR = 1.08, 95% CI 1.01-1.15, P = 0.02). Genome wide association (GWA) analysis of over 300 000 SNPs on 11 219 subjects did not identify any additional variants related to smoking behaviour. This study confirms the strong association between 15q gene variants and LC and shows an independent association with smoking quantity, as well as an association with UADT cancers.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
005-1080315-0294 - Odrednice multiplih primarnih sijela raka u populaciji (Znaor, Ariana, MZOS ) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo

Profili:

Avatar Url Ariana Znaor (autor)

Poveznice na cjeloviti tekst rada:

doi e-bea.ovid.com ovidsp.tx.ovid.com

Citiraj ovu publikaciju:

Lips, E.H.; Gaborieau, V.; McKay, J.D.; Chabrier, A.; Hung, R.J.; Boffetta, P.; Hashibe, M.; Zaridze, D.; Szeszenia-Dabrowska, N.; Lissowska, J. et al.
Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals // International journal of epidemiology, 39 (2010), 2; 563-577 doi:10.1093/ije/dyp288 (međunarodna recenzija, članak, znanstveni)
Lips, E., Gaborieau, V., McKay, J., Chabrier, A., Hung, R., Boffetta, P., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N. & Lissowska, J. (2010) Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. International journal of epidemiology, 39 (2), 563-577 doi:10.1093/ije/dyp288.
@article{article, author = {Lips, E.H. and Gaborieau, V. and McKay, J.D. and Chabrier, A. and Hung, R.J. and Boffetta, P. and Hashibe, M. and Zaridze, D. and Szeszenia-Dabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Mates, D. and Bencko, V. and Foretova, L. and Janout, V. and Field, J.K. and Liloglou, T. and Xinarianos, G. and McLaughlin, J. and Liu, G. and Skorpen, F. and Elvestad, M.B. and Hveem, K. and Vatten, L. and Study, E. and Benhamou, S. and Lagiou, P. and Holc\'{a}tov\'{a}, I. and Merletti, F. and Kjaerheim, K. and Agudo, A. and Castellsagu\'{e}, X. and Macfarlane, T.V. and Barzan, L. and Canova, C. and Lowry, R. and Conway, D.I. and Znaor, Ariana and Healy, C. and Curado, M.P. and Koifman, S. and Eluf-Neto, J. and Matos, E. and Menezes, A. and Fernandez, L. and Metspalu, A. and Heath, S. and Lathrop, M. and Brennan, P.}, year = {2010}, pages = {563-577}, DOI = {10.1093/ije/dyp288}, keywords = {upper aerodigestive tract cancers, smoking quantity, 15q25 gene variant}, journal = {International journal of epidemiology}, doi = {10.1093/ije/dyp288}, volume = {39}, number = {2}, issn = {0300-5771}, title = {Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals}, keyword = {upper aerodigestive tract cancers, smoking quantity, 15q25 gene variant} }
@article{article, author = {Lips, E.H. and Gaborieau, V. and McKay, J.D. and Chabrier, A. and Hung, R.J. and Boffetta, P. and Hashibe, M. and Zaridze, D. and Szeszenia-Dabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Mates, D. and Bencko, V. and Foretova, L. and Janout, V. and Field, J.K. and Liloglou, T. and Xinarianos, G. and McLaughlin, J. and Liu, G. and Skorpen, F. and Elvestad, M.B. and Hveem, K. and Vatten, L. and Study, E. and Benhamou, S. and Lagiou, P. and Holc\'{a}tov\'{a}, I. and Merletti, F. and Kjaerheim, K. and Agudo, A. and Castellsagu\'{e}, X. and Macfarlane, T.V. and Barzan, L. and Canova, C. and Lowry, R. and Conway, D.I. and Znaor, Ariana and Healy, C. and Curado, M.P. and Koifman, S. and Eluf-Neto, J. and Matos, E. and Menezes, A. and Fernandez, L. and Metspalu, A. and Heath, S. and Lathrop, M. and Brennan, P.}, year = {2010}, pages = {563-577}, DOI = {10.1093/ije/dyp288}, keywords = {upper aerodigestive tract cancers, smoking quantity, 15q25 gene variant}, journal = {International journal of epidemiology}, doi = {10.1093/ije/dyp288}, volume = {39}, number = {2}, issn = {0300-5771}, title = {Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals}, keyword = {upper aerodigestive tract cancers, smoking quantity, 15q25 gene variant} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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