Naslov
Changes of brain metabolites measured with magnetic spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder

Autori
Henigsberg N, Bajs M, Hrabač P, Kalember P, Radoš M, Radoš M, Radonić E

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
The third croatian congress of neuroscience ; knjiga sažetaka / - , 2009, 47-47

Skup
3. Croatian congress of neuroscience

Mjesto i datum
Zadar, Hrvatska, 24.09.2009. - 26.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
brain metabolites; spectroscopy; antidepressant responders; major depression; PTSP

Sažetak
Introduction: In a present pilot study, performed on 11 subjects, we studied proton magnetic resonance spectroscopy (1H‐MRS) changes in early to intermediate (3‐6 weeks) responders to antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs). All subjects had diagnosis of major recurrent depression comorbid to posttraumatic stress disorder (PTSD). Subjects and methods: Magnetic spectroscopy was done in the region of dorsolateral prefrontal cortex on a 3T MRI‐unit. Participants were selected out of the larger sample due to an early response to antidepressant treatment within 3‐6 weeks, measured with Beck Depression Inventory (BDI). We measured levels of neuronal marker N‐acetyl‐ aspartate (NAA), choline (CHO) and creatine (CRE). Results: There was no difference in NAA/CRE ratios at the first and second spectroscopy (p=0, 514). However, CHO/CRE ratios showed different trend with mean value at the first spectroscopy of 1, 07 (sd=0, 12) while mean value at second was 1, 22 (sd=0, 08) with statistical significance with p‐ value of 0, 003. In conclusion, significant increase in choline to creatine ratio from the first to the second spectroscopy during the antidepressant treatment, compared to almost identical values of NAA to creatine ratio, suggests increased turnover of cell membranes as a mechanism of the early response to the antidepressant drug therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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