Naslov
1‐H MRS changes in dorsolateral prefrontal cortex after donepezil treatment in patients with mild to moderate Alzheimer's disease

Autori
Henigsberg, N. ; Kalember, P. ; Hrabač, P. ; Radoš, Marenka ; Bajs, M. ; Radoš, Marko ; Kovačić, Z. ; Lončar, M. ; Madžar, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. Croatian congress on neuroscience: Abstracts / - , 2009

Skup
Croatian congress on neuroscience (3 ; 2009)

Mjesto i datum
Zadar, Hrvatska, 24.09.2009. - 26.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
DLPFC changes; donepezil; Alzheimer's disease

Sažetak
Magnetic resonance spectroscopy (MRS) noninvasively provides information on the concentration of some cerebral metabolites in vivo. Among those measurable by proton magnetic resonance spectroscopy (1H‐MRS), N‐acetyl‐aspartate (NAA) is decreased, and myo‐inositol (mI) and choline (Cho) levels are increased in patients with Alzheimer's disease (AD). Donepezil, an acetylcholinesteraze inhibitor, has proven effect on cognitive symptoms in patients with AD. In previous studies, treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe and hippocampi. Correlation of longitudinal changes of 1H‐MRS detectable metabolites in dorsolateral prefrontal cortex (DLPFC) with clinically observable changes were not researched. The objective of this non‐interventional study is to assess whether changes in 1H‐MRS measurable metabolites correlate with clinical outcome after donepezil treatment. Twelfe patients with mild to moderate AD were evaluated during 26 weeks of donepezil treatment. 1H‐MRS parameters were assessed before and after 26 weeks of donepezil treatment. Cognition was assessed with Alzheimer's Disease Assessment Scale cognitive subscale. A significant increase in NAA/Cr ratio and significantly lower decrease in mI/Cr ratio were found in AD patients with positive treatment response. The results of this study indicate possible modest donepezil effect on prevention of neuronal functional deterioration in DLPFC which correlates with clinical outcome and point the use of 1HMRS as technique of help in assessment of drug effect.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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