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Pregled bibliografske jedinice broj: 463735

Body weight as a predictor of antidepressant efficacy in the GENDEP project

Uher, Rudolf; Mors, Ole; Hauser, Joanna; Rietschel, Marcella; Maier, Wolfgang; Kozel, Dejan; Henigsberg, Neven; Souery, Daniel; Placentino, Anna; Perroud, nader et al.
Body weight as a predictor of antidepressant efficacy in the GENDEP project // Journal of affective disorders, 118 (2009), 1-3; 147-154 doi:10.1016/j.jad.2009.02.013 (međunarodna recenzija, članak, znanstveni)

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Naslov
Body weight as a predictor of antidepressant efficacy in the GENDEP project

Autori
Uher, Rudolf ; Mors, Ole ; Hauser, Joanna ; Rietschel, Marcella ; Maier, Wolfgang ; Kozel, Dejan ; Henigsberg, Neven ; Souery, Daniel ; Placentino, Anna ; Perroud, nader ; Dernovsek, Moica Zvezdana ; Strohmaier, Jana ; Larsen, Erik Roj ; Zobel, Astrid ; Leszczynska-Rodziewicz, Anna ; Kalember, Petra ; Pedrini, Laura ; Linotte, Sylvie ; Gunasinghe, Cerisse ; Aitchison, Katherine J. ; McGuffin, Peter ; Farmer Anne

Izvornik
Journal of affective disorders (0165-0327) 118 (2009), 1-3; 147-154

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
depression; antidepressant medication; body weight; body mass index; psychopharmacology; psychosomatics

Sažetak
Being overweight or obese may be associated with poor response to antidepressants. The present report explores the moderation of antidepressant response by body weight to establish the specificity to antidepressant mode of action, type of depressive symptoms and gender. Height and weight were measured in 797 men and women with major depression treated with escitalopram or nortriptyline for twelve weeks as part of the Genome Based Therapeutic Drugs for Depression (GENDEP) project. Body mass index (BMI) and obesity (BMI>30) were tested as predictors of change in depressive symptoms using mixed linear models. Higher BMI and obesity predicted poor response to nortriptyline but did not significantly influence response to escitalopram. The moderation of response by body weight was due to differential improvement in neurovegetative symptoms, including sleep and appetite. The relationship between body weight and change in neurovegetative symptoms was moderated by gender with obese men responding less to nortriptyline and obese women having poorer response to both antidepressants. As no placebo arm was included, the specificity of findings to antidepressants is relative. Lack of specific measures precluded accounting for differences in body fat distribution. Body weight should be considered in the assessment of depression as it may inform the selection of antidepressant treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Uher, Rudolf; Mors, Ole; Hauser, Joanna; Rietschel, Marcella; Maier, Wolfgang; Kozel, Dejan; Henigsberg, Neven; Souery, Daniel; Placentino, Anna; Perroud, nader et al.
Body weight as a predictor of antidepressant efficacy in the GENDEP project // Journal of affective disorders, 118 (2009), 1-3; 147-154 doi:10.1016/j.jad.2009.02.013 (međunarodna recenzija, članak, znanstveni)
Uher, R., Mors, O., Hauser, J., Rietschel, M., Maier, W., Kozel, D., Henigsberg, N., Souery, D., Placentino, A. & Perroud, n. (2009) Body weight as a predictor of antidepressant efficacy in the GENDEP project. Journal of affective disorders, 118 (1-3), 147-154 doi:10.1016/j.jad.2009.02.013.
@article{article, author = {Uher, Rudolf and Mors, Ole and Hauser, Joanna and Rietschel, Marcella and Maier, Wolfgang and Kozel, Dejan and Henigsberg, Neven and Souery, Daniel and Placentino, Anna and Perroud, nader and Dernovsek, Moica Zvezdana and Strohmaier, Jana and Larsen, Erik Roj and Zobel, Astrid and Leszczynska-Rodziewicz, Anna and Kalember, Petra and Pedrini, Laura and Linotte, Sylvie and Gunasinghe, Cerisse and Aitchison, Katherine J. and McGuffin, Peter}, year = {2009}, pages = {147-154}, DOI = {10.1016/j.jad.2009.02.013}, keywords = {depression, antidepressant medication, body weight, body mass index, psychopharmacology, psychosomatics}, journal = {Journal of affective disorders}, doi = {10.1016/j.jad.2009.02.013}, volume = {118}, number = {1-3}, issn = {0165-0327}, title = {Body weight as a predictor of antidepressant efficacy in the GENDEP project}, keyword = {depression, antidepressant medication, body weight, body mass index, psychopharmacology, psychosomatics} }
@article{article, author = {Uher, Rudolf and Mors, Ole and Hauser, Joanna and Rietschel, Marcella and Maier, Wolfgang and Kozel, Dejan and Henigsberg, Neven and Souery, Daniel and Placentino, Anna and Perroud, nader and Dernovsek, Moica Zvezdana and Strohmaier, Jana and Larsen, Erik Roj and Zobel, Astrid and Leszczynska-Rodziewicz, Anna and Kalember, Petra and Pedrini, Laura and Linotte, Sylvie and Gunasinghe, Cerisse and Aitchison, Katherine J. and McGuffin, Peter}, year = {2009}, pages = {147-154}, DOI = {10.1016/j.jad.2009.02.013}, keywords = {depression, antidepressant medication, body weight, body mass index, psychopharmacology, psychosomatics}, journal = {Journal of affective disorders}, doi = {10.1016/j.jad.2009.02.013}, volume = {118}, number = {1-3}, issn = {0165-0327}, title = {Body weight as a predictor of antidepressant efficacy in the GENDEP project}, keyword = {depression, antidepressant medication, body weight, body mass index, psychopharmacology, psychosomatics} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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