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Pregled bibliografske jedinice broj: 463716

Moderation of antidepressant response by the serotonin transporter gene

Huezo-Diaz, Patricia; Uher, Rudolf; Smith, Rebecca; Rietschel, Marcella; Henigsberg, Neven; Marušić , Andrej; Mors, Ole; Maier, Wolfgang; Hauser, Joanna; Souery, Daniel et al.
Moderation of antidepressant response by the serotonin transporter gene // British journal of psychiatry, 195 (2009), 1; 30-38 doi:10.1192/bjp.bp.108.062521 (međunarodna recenzija, članak, znanstveni)

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Naslov
Moderation of antidepressant response by the serotonin transporter gene

Autori
Huezo-Diaz, Patricia ; Uher, Rudolf ; Smith, Rebecca ; Rietschel, Marcella ; Henigsberg, Neven ; Marušić , Andrej ; Mors, Ole ; Maier, Wolfgang ; Hauser, Joanna ; Souery, Daniel ; Placentino, Anna ; Zobel, Astrid ; Roj Larsen, Erik ; Czerski, Piotr M. ; Gupta, Bhanu ; Hoda, Farzana ; Perroud, Nader ; Farmer, Anne ; Craig, Ian ; Aitchison Katherine J. ; McGuffin, Peter

Izvornik
British journal of psychiatry (0007-1250) 195 (2009), 1; 30-38

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antidepressant response; serotonin transport gene

Sažetak
There have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene. Aims were to test the hypothesis that the 5- HTTLPR differently influences response to escitalopram (an SSRI) compared with nortriptyline (a noradrenaline reuptake inhibitor). The 5-HTTLPR and 13 additional markers across the serotonin transporter gene were genotyped in 795 adults with moderate-to- severe depression treated with escitalopram or nortriptyline in the Genome Based Therapeutic Drugs for Depression (GENDEP) project. The 5- HTTLPR moderated the response to escitalopram, with long-allele carriers improving more than short-allele homozygotes. A significant three- way interaction between 5-HTTLPR, drug and gender indicated that the effect was concentrated in males treated with escitalopram. The single-nucleotide polymorphism rs2020933 also influenced outcome. The effect of 5-HTTLPR on antidepressant response is SSRI specific conditional on gender and modulated by another polymorphism at the 5' end of the serotonin transporter gene.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi bjp.rcpsych.org

Citiraj ovu publikaciju:

Huezo-Diaz, Patricia; Uher, Rudolf; Smith, Rebecca; Rietschel, Marcella; Henigsberg, Neven; Marušić , Andrej; Mors, Ole; Maier, Wolfgang; Hauser, Joanna; Souery, Daniel et al.
Moderation of antidepressant response by the serotonin transporter gene // British journal of psychiatry, 195 (2009), 1; 30-38 doi:10.1192/bjp.bp.108.062521 (međunarodna recenzija, članak, znanstveni)
Huezo-Diaz, P., Uher, R., Smith, R., Rietschel, M., Henigsberg, N., Marušić , A., Mors, O., Maier, W., Hauser, J. & Souery, D. (2009) Moderation of antidepressant response by the serotonin transporter gene. British journal of psychiatry, 195 (1), 30-38 doi:10.1192/bjp.bp.108.062521.
@article{article, author = {Huezo-Diaz, Patricia and Uher, Rudolf and Smith, Rebecca and Rietschel, Marcella and Henigsberg, Neven and Maru\v{s}i\'{c}, Andrej and Mors, Ole and Maier, Wolfgang and Hauser, Joanna and Souery, Daniel and Placentino, Anna and Zobel, Astrid and Roj Larsen, Erik and Czerski, Piotr M. and Gupta, Bhanu and Hoda, Farzana and Perroud, Nader and Farmer, Anne and Craig, Ian and McGuffin, Peter}, year = {2009}, pages = {30-38}, DOI = {10.1192/bjp.bp.108.062521}, keywords = {antidepressant response, serotonin transport gene}, journal = {British journal of psychiatry}, doi = {10.1192/bjp.bp.108.062521}, volume = {195}, number = {1}, issn = {0007-1250}, title = {Moderation of antidepressant response by the serotonin transporter gene}, keyword = {antidepressant response, serotonin transport gene} }
@article{article, author = {Huezo-Diaz, Patricia and Uher, Rudolf and Smith, Rebecca and Rietschel, Marcella and Henigsberg, Neven and Maru\v{s}i\'{c}, Andrej and Mors, Ole and Maier, Wolfgang and Hauser, Joanna and Souery, Daniel and Placentino, Anna and Zobel, Astrid and Roj Larsen, Erik and Czerski, Piotr M. and Gupta, Bhanu and Hoda, Farzana and Perroud, Nader and Farmer, Anne and Craig, Ian and McGuffin, Peter}, year = {2009}, pages = {30-38}, DOI = {10.1192/bjp.bp.108.062521}, keywords = {antidepressant response, serotonin transport gene}, journal = {British journal of psychiatry}, doi = {10.1192/bjp.bp.108.062521}, volume = {195}, number = {1}, issn = {0007-1250}, title = {Moderation of antidepressant response by the serotonin transporter gene}, keyword = {antidepressant response, serotonin transport gene} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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