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Pregled bibliografske jedinice broj: 463691

Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project

Perroud, N.; ...; Marušić, Andrej; ...; Henigsberg, Neven; ...; Petrović, Ana; Kalember, Petra; ...; Craig, I.
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project // Neuropsychopharmacology, 34 (2009), 12; 2517-2528 doi:0.1038/npp.2009.81 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 463691 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project

Autori
Perroud, N. ; ... ; Marušić, Andrej ; ... ; Henigsberg, Neven ; ... ; Petrović, Ana ; Kalember, Petra ; ... ; Craig, I.

Izvornik
Neuropsychopharmacology (0893-133X) 34 (2009), 12; 2517-2528

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adverse events; antidepressants

Sažetak
The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF (p=0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2, the gene encoding the BNDF receptor (p=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha(2A)-adrenergic receptor gene (ADRA2A) (p=0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1880 - 1H-MRS promjene u predviđanju terapijskog odgovora, relapsa i povrata depresije (Henigsberg, Neven, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com www.nature.com

Citiraj ovu publikaciju:

Perroud, N.; ...; Marušić, Andrej; ...; Henigsberg, Neven; ...; Petrović, Ana; Kalember, Petra; ...; Craig, I.
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project // Neuropsychopharmacology, 34 (2009), 12; 2517-2528 doi:0.1038/npp.2009.81 (međunarodna recenzija, članak, znanstveni)
Perroud, N., ..., Marušić, A., ..., Henigsberg, N., ..., Petrović, A., Kalember, P., ... & Craig, I. (2009) Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project. Neuropsychopharmacology, 34 (12), 2517-2528 doi:0.1038/npp.2009.81.
@article{article, author = {Perroud, N. and Maru\v{s}i\'{c}, Andrej and Henigsberg, Neven and Petrovi\'{c}, Ana and Kalember, Petra and Craig, I.}, year = {2009}, pages = {2517-2528}, DOI = {0.1038/npp.2009.81}, keywords = {adverse events, antidepressants}, journal = {Neuropsychopharmacology}, doi = {0.1038/npp.2009.81}, volume = {34}, number = {12}, issn = {0893-133X}, title = {Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project}, keyword = {adverse events, antidepressants} }
@article{article, author = {Perroud, N. and Maru\v{s}i\'{c}, Andrej and Henigsberg, Neven and Petrovi\'{c}, Ana and Kalember, Petra and Craig, I.}, year = {2009}, pages = {2517-2528}, DOI = {0.1038/npp.2009.81}, keywords = {adverse events, antidepressants}, journal = {Neuropsychopharmacology}, doi = {0.1038/npp.2009.81}, volume = {34}, number = {12}, issn = {0893-133X}, title = {Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project}, keyword = {adverse events, antidepressants} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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