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Pregled bibliografske jedinice broj: 463648

Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project

Keers, R.; Uher, R.; Huezo-Diaz, P.; Smith, R.; Jaffee, S.; Rietschel, M.; Henigsberg, Neven; Kozel, D.; Mors, O.; Maier, W. et al.
Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project // Pharmacogenomics journal, 11 (2011), 138-145 doi:10.1038/tpj.2010.14 (međunarodna recenzija, članak, znanstveni)

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Naslov
Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project

Autori
Keers, R. ; Uher, R. ; Huezo-Diaz, P. ; Smith, R. ; Jaffee, S. ; Rietschel, M. ; Henigsberg, Neven ; Kozel, D. ; Mors, O. ; Maier, W. ; Zobel, A. ; Hauser, J. ; Souery, D. ; Placentino, A. ; Larsen, E.R., ; Dmitrzak-Weglarz, M. ; Gupta, B. ; Hoda, F. ; Craig, I. ; McGuffin, P. ; Farmer, A.E. ; Aitchison, K.J.

Izvornik
Pharmacogenomics journal (1470-269X) 11 (2011); 138-145

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
depression; antidepressive agents; pharmacogenetics; serotonin transporter; gene–environment interaction; stressful life events

Sažetak
There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example, there is evidence to suggest that variation in the serotonin transporter gene (SLC6A4) predicts response to selective serotonin reuptake inhibitors (SSRIs). Environmental factors such as the occurrence of stressful life events before treatment may also be important. One prior report suggests that both factors interact in predicting response to antidepressants. GENDEP, a prospective part-randomized pharmacogenomics trial, collected longitudinal data on the outcome of 811 patients with major depression undergoing treatment with either an SSRI (escitalopram) or a tricyclic antidepressant (nortriptyline). Life events experienced over 6 months preceding treatment were measured using a List of Threatening Experiences Questionnaire, and several polymorphisms in the serotonin transporter gene (SLC6A4) have been genotyped including the serotonin transporter-linked polymorphic region (5-HTTLPR). Stressful life events were shown to predict a significantly better response to escitalopram but had no effect on response to nortriptyline. Variation in the 5-HTTLPR and another polymorphism in the gene, STin4, significantly modified these effects. Gene-environment interactions including life events may therefore be important not only in the aetiology of depression, but also in predicting response to antidepressant medication.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1880 - 1H-MRS promjene u predviđanju terapijskog odgovora, relapsa i povrata depresije (Henigsberg, Neven, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Keers, R.; Uher, R.; Huezo-Diaz, P.; Smith, R.; Jaffee, S.; Rietschel, M.; Henigsberg, Neven; Kozel, D.; Mors, O.; Maier, W. et al.
Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project // Pharmacogenomics journal, 11 (2011), 138-145 doi:10.1038/tpj.2010.14 (međunarodna recenzija, članak, znanstveni)
Keers, R., Uher, R., Huezo-Diaz, P., Smith, R., Jaffee, S., Rietschel, M., Henigsberg, N., Kozel, D., Mors, O. & Maier, W. (2011) Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project. Pharmacogenomics journal, 11, 138-145 doi:10.1038/tpj.2010.14.
@article{article, author = {Keers, R. and Uher, R. and Huezo-Diaz, P. and Smith, R. and Jaffee, S. and Rietschel, M. and Henigsberg, Neven and Kozel, D. and Mors, O. and Maier, W. and Zobel, A. and Hauser, J. and Souery, D. and Placentino, A. and Dmitrzak-Weglarz, M. and Gupta, B. and Hoda, F. and Craig, I. and McGuffin, P. and Farmer, A.E. and Aitchison, K.J.}, year = {2011}, pages = {138-145}, DOI = {10.1038/tpj.2010.14}, keywords = {depression, antidepressive agents, pharmacogenetics, serotonin transporter, gene–environment interaction, stressful life events}, journal = {Pharmacogenomics journal}, doi = {10.1038/tpj.2010.14}, volume = {11}, issn = {1470-269X}, title = {Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project}, keyword = {depression, antidepressive agents, pharmacogenetics, serotonin transporter, gene–environment interaction, stressful life events} }
@article{article, author = {Keers, R. and Uher, R. and Huezo-Diaz, P. and Smith, R. and Jaffee, S. and Rietschel, M. and Henigsberg, Neven and Kozel, D. and Mors, O. and Maier, W. and Zobel, A. and Hauser, J. and Souery, D. and Placentino, A. and Dmitrzak-Weglarz, M. and Gupta, B. and Hoda, F. and Craig, I. and McGuffin, P. and Farmer, A.E. and Aitchison, K.J.}, year = {2011}, pages = {138-145}, DOI = {10.1038/tpj.2010.14}, keywords = {depression, antidepressive agents, pharmacogenetics, serotonin transporter, gene–environment interaction, stressful life events}, journal = {Pharmacogenomics journal}, doi = {10.1038/tpj.2010.14}, volume = {11}, issn = {1470-269X}, title = {Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project}, keyword = {depression, antidepressive agents, pharmacogenetics, serotonin transporter, gene–environment interaction, stressful life events} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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