Naslov
Role of H. pylori eradication therapy success on five year dynamics of atrophic gastritis and intestinal metaplasia grade

Autori
Filipec Kanižaj, Tajana ; Katičić, Miroslava ; Škurla, Bruno ; Prskalo, Marija ; Čolić-Cvrlje, Vesna ; Naumovski-Mihalić, Slavica ; Mrzljak, Anna ; Šabarić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter / Graham, DY - Oxford : Wiley-Blackwell, 2009, 329-329

Skup
XXII International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflamation and Gastric Cancer

Mjesto i datum
Porto, Portugal, 17.09.2009. - 19.09.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; eradication therapy success; atrophic gastritis; intestinal metaplasia

Sažetak
Aim: to investigate the role of eradication therapy success on five year dynamics of atrophic gastritis and intestinal metaplasia. Materials and methods: study was performed on 186 H. pylori positive patients with atrophic gastritis and/or intestinal metaplasia in basic bioptic specimens analyzed according to updated Sydney protocol. All patients received triple eradication therapy. Therapy success and dynamics of histopathological parameters were evaluated according to 5th year histological finding. Results: basically 50 patients had atrophic gastritis in corpus and 62 in antrum, 60 intestinal metaplasia in corpus and 116 in antrum mucosa. H. pylori was successfully eradicated in 157 patients. In successfully eradicated, regression/progression/no dynamics in grade of atrophic gastritis revealed 28, 66/1, 27/70, 06% patients in corpus and 33, 76/0, 64/65, 61% in antrum mucosa respectively. Accordingly, 19, 11/3, 82/77, 07% with intestinal metaplasia in corpus and 41, 40/10, 19/48, 41% in antrum. In non- eradicated patients: 13, 79/6, 90/79, 31% with atrophic gastritis in corpus, 20, 69/10, 34/68, 97% atrophic gastritis in antrum, 24, 14/6, 90/68, 97% intestinal metaplasia in corpus and 31, 03/13, 79/55, 17% in antrum. Statistically significant dynamics of grade of both histological parameters was observed for successfully eradicated patients only (Wilcox rank sum test, p<0, 001). By multivariate analysis unsuccessful eradication therapy was predictor of progression of grade of atrophic gastritis on both anatomic localisations (antrum p=0, 014, corpus p<0, 001). Conclusions: successful H. pylori eradication is related with statistically significant dynamics in grade of both histological parameters. Proportion of patents with regression of atrophic gastritis is statistically significantly higher in successfully eradicated patients than non- eradicated. Unsuccessful eradication is predictor of progression of grade of atrophic gastritis on both localisations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA