Naslov
Parvovirus B19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation

Autori
Mrzljak, Anna ; Kardum-Skelin, Ika ; Čolić-Cvrlje, Vesna ; Filipec Kanižaj, Tajana ; Šušterčić, Dunja ; Guštin, Denis ; Kocman, Branislav

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 1; 271-274

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, znanstveni

Ključne riječi
pure red cell aplasia (PRCA); parvovirus B19 (PVB19); liver transplantation

Sažetak
Reported here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppression or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in transplanted patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA