Naslov
Intraoperative Imprint Cytological Assessment of the Subareolar Tissue of the Nipple Areola Complex (NAC)

Autori
Tomasović-Lončarić, Čedna ; Milanović, Rudolf ; Lambaša, Smiljka ; Križanac, Šimun ; Štoos-Veić, Tajana ; Kaić, Gordana ; Trutin Ostović, Karmen

Izvornik
Collegium Antropologicum (0350-6134) 34 (2010), 2; 431-435

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
intraoperative imprint cytology; NAC base; nipple areola complex preservation
(intraoperative imprint cytology; NAC base; nipple areola complex preservationNAC)

Sažetak
One of the criteria of selection for skin sparing mastectomy nipple areola complex preservation is to exclude the neoplastic involvement of subareolar tissue in order to minimize the possibility of local recurrence. The most common way to assess the possible neoplastic involvement is intraoperative frozen section of the NAC base tissue. Because of its limitations, particularly the false negative results due to unsampling we tried to use intraoperative imprint cytology for more thorough intraoperative assessment. The aim was to compare intraoperative imprint findings with the definitive histology of the NAC base, to evaluate diagnostic accuracy of this method and possibility to substitute frozen section for intraoperative assessment of NAC base. A prospective clinical study was conducted of 208 consecutive female patients who underwent open biopsy because of carcinoma. Intraoperative imprints were taken from the excised subareolar tissue which was then routinely processed for definitive histology. Imprint findings designated positive, negative, suspicious or atypia, were compared with definitive histological findings. Our results with 7, 5% false negative rate, 9, 8% false positive rate, sensitivity of 50% and specificity of 87, 58% argue that imprint cytology might not be sufficient as an exclusive method for the intraoperative assessment of the NAC base though it should be used routinely in conjunction with frozen section examination.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA