Naslov
Environmental enrichment and mental training improve cognition in rat model of sporadic alzheimer’s disease

Autori
Osmanović, Jelena ; Šalković-Petrišić, Melita ; Hoyer, Siegfried ; Riederer, Peter

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 9th International Conference AD/PD ""Alzheimer's and Parkinson's Diseases: Advances, Concepts and New Challenges" ; u: Neurodegenerative Diseases 6 (2009) (S1) / Fisher, A. ; Hanin, I. ; Nitsch, R.M. ; Windisch, M. - , 2009

ISBN
978-3-8055-9118-8

Skup
International conference AD/PD "Alzheimer's and Parkinson's Diseases: Advances, Concepts and New Challenges" (9 ; 2009)

Mjesto i datum
Prag, Češka Republika, 11.03.2009. - 15.03.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sporadic alzheimer disease; cognitive impairments; streptozotocin; memory deficit

Sažetak
Growing body of evidence suggests that physical and mental activities have beneficial effects on cognitive impairments in Alzheimer’s disease (AD). However, the effect of long lasting cognitive and physical stimulation has been evaluated only in transgenic mice, representing the familial AD form. We investigated whether the long-term enriched housing and intensive cognitive training could improve learning and memory deficits in sporadic AD (sAD) animal model, i.e. in streptozotocin-intracerebroventricularly (STZ-icv) treated rats. Adult, male Wistar rats (N=40) were randomly divided in 2 groups, which, following the general anaesthesia, were given icv injection of STZ (3 mg/kg) or vehicle, respectively. Three weeks after STZ-icv treatment, one half of each group was rendered to enriched housing (EH) and intensive weekly mental training in the Morris Water Maze Swimming (MWM) test and Dray maze (DM) for another 9 weeks. Mann-Whitney U-test (p<0.05) was used for data analysis. Significant deficit in learning and memory functions (-29%, MWM) and increased anxiety (+142%, DM) with decrease in moving (-31%, DM) were found in STZ-icv treated rats, in comparison with the controls, 3 weeks following the icv treatment. Changes persisted up to 3 months in rats not subjected to EH and mental training but were normalised and insignificant in STZ-icv rats previously subjected to EH and mental training. Results indicated that intensive and long-term mental and psychical activity may improve cognition and normalize memory loos and anxiety in STZ-icv rat model of sAD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
E-ISBN: 978-3-8055-9119-5

POVEZANOST RADA