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Pregled bibliografske jedinice broj: 462766

Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study

Skelin, Ivan; Sato, Hiroki; Dikšić, Mirko
Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study // Brain research, 1310 (2010), 162-171 doi:10.1016/j.brainres.2009.11.006 (međunarodna recenzija, članak, znanstveni)

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Naslov
Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study

Autori
Skelin, Ivan ; Sato, Hiroki ; Dikšić, Mirko

Izvornik
Brain research (0006-8993) 1310 (2010); 162-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
olfactory bulbectomy; model of depression; 2-[14C] deoxyglucose; autoradiography; d-fenfluramine; seroton

Sažetak
The olfactory bulbectomized (OBX) rat is an animal model of depression with neurochemical, neuroendocrinological and behavioral features resembling some human depression. d-Fenfluramine is a 5-HT releasing drug, frequently used in the study of the responsivity of the 5-HT system in subjects with psychiatric disorders, including depression. The aim of the study is to assess the influence of the serotonin-releaser, d-fenfluramine, in the OBX rat model of depression, as measured by the change in the regional cerebral glucose utilization rCGU) following d-fenfluramine injection. Male Sprague–Dawley rats (160–180 g) were used. The rats were divided into OBX and Sham groups. Two weeks following the olfactory bulbectomy or the sham surgery, six rats (randomly assigned) from each group received an i.p. injection of d-fenfluramine with a dose of 5 mg/kg or the same volume of saline. Twenty minutes later, the rCGU rates were measured using 2-[14C]deoxyglucose autoradiography. The general linear model statistical analysis has shown that the rCGU in the sham-operated rats treated with d-fenfluramine, compared to the sham-operated rats treated with saline, was lower in 14 (36%) out of 39 examined brain regions. There was no significant difference in the rCGU between the OBX rats treated with d-fenfluramine and OBX rats treated with saline. The results suggest the blunted capacity of the 5-HT system in OBX rats to respond to the challenge by the 5-HT releasing compound, d-fenfluramine. This resembles similar findings in clinical studies on depressed patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
219-1081870-2032 - Serotoninski receptori te promjena antidepresivima u štakorskom modelu depresije (Dikšić, Mirko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mirko Dikšić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Skelin, Ivan; Sato, Hiroki; Dikšić, Mirko
Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study // Brain research, 1310 (2010), 162-171 doi:10.1016/j.brainres.2009.11.006 (međunarodna recenzija, članak, znanstveni)
Skelin, I., Sato, H. & Dikšić, M. (2010) Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study. Brain research, 1310, 162-171 doi:10.1016/j.brainres.2009.11.006.
@article{article, author = {Skelin, Ivan and Sato, Hiroki and Dik\v{s}i\'{c}, Mirko}, year = {2010}, pages = {162-171}, DOI = {10.1016/j.brainres.2009.11.006}, keywords = {olfactory bulbectomy, model of depression, 2-[14C] deoxyglucose, autoradiography, d-fenfluramine, seroton}, journal = {Brain research}, doi = {10.1016/j.brainres.2009.11.006}, volume = {1310}, issn = {0006-8993}, title = {Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study}, keyword = {olfactory bulbectomy, model of depression, 2-[14C] deoxyglucose, autoradiography, d-fenfluramine, seroton} }
@article{article, author = {Skelin, Ivan and Sato, Hiroki and Dik\v{s}i\'{c}, Mirko}, year = {2010}, pages = {162-171}, DOI = {10.1016/j.brainres.2009.11.006}, keywords = {olfactory bulbectomy, model of depression, 2-[14C] deoxyglucose, autoradiography, d-fenfluramine, seroton}, journal = {Brain research}, doi = {10.1016/j.brainres.2009.11.006}, volume = {1310}, issn = {0006-8993}, title = {Acute challenge with d-fenfluramine decreases regional cerebral glucose utilization in Sham, but not in OBX, rats : an autoradiographic study}, keyword = {olfactory bulbectomy, model of depression, 2-[14C] deoxyglucose, autoradiography, d-fenfluramine, seroton} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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