Naslov
Codon usage bias in metagenomes

Autori
Lucić, Vedran ; Perica, Tina ; Roller Milošević, Maša ; Vlahoviček, Kristian

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, The 3rd Adriatic Meeting on Computational Solutions in Life Sciences / - Zagreb, 2009, 64-64

ISBN
978-953-6690-80-0

Skup
The 3rd Adriatic Meeting On Computational Solutions in the Life Sciences

Mjesto i datum
Primošten, Hrvatska, 01.09.2009. - 05.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
metegenomes; codon; bioinformatics

Sažetak
Codon usage (CU) bias is an effect predominant in prokaryotes whereby synonymous codons are used with different frequencies between different species and even between genes within a single genome. This effect is related to tRNA abundance and can be used to predict expressivity of proteins by comparing their CU with that of a reference set of housekeeping genes. Our aim was to investigate codon usage patterns within metagenomic sequences and test for a presence or absence of CU bias at the level of a microbial community. We investigated synonymous CU frequencies in three metagenome samples and have demonstrated that a) different metagenomes exhibit different patterns in codon usage, and b) gene functions within a metagenome with high predicted expressivity (compared to the meta-ribosomal set) correlate well with the ecological requirements within the environment, suggesting that different species within a microbial community indeed behave as a meta-genome.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA