Naslov
Effect of intrauterine growth retardation on circadian blood pressure regulation in persons with newly diagnosed essential hypertension - a preliminary report

Autori
Laganović, Mario ; Kuzmanić, Duško ; Premužić, Vedran ; Vuković, Ivana ; Pećin, Ivan ; Boršo, Gordana ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Central European Meeting on Hypertension ; u: Kidney & blood pressure research 32 (2009) (5) 309-333 ; Poster Presentations, 316-331 ; P-V6 / Cífková, R. ; Jelaković, Bojan - , 2009, 330-331

Skup
Central European Meeting on Hypertension (5 ; 2009)

Mjesto i datum
Zagreb, Hrvatska, 22.10.2009. - 25.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Blood Pressure; Intrauterine; Growth Retardation

Sažetak
Intrauterine growth retardation has been reported to be related with adult hypertension, kidney disease, and increased cardiovascular riskrisk. Our aim was to assess a possible relationship between IUGR and circadian blood pressure (BP) in newly diagnosed essential hypertension (EH). Anthropometric characteristics were determined in 58 (33 M and 25 F, mean age: 33.8 + 8.5 years) newly diagnosed, untreated EH patients without target organ damage and a negative family history of hypertension: 46 with normal birth parameters (NBW) and 12 with IUGR. BP was measured in the sitting position using a mercury sphygmomanometer and a Spacelabs 90207 ambulatory BP monitor (ABPM) device. Birth parameters were obtained from medical records. IUGR patients were defined as a birth weight under the 10th percentile for gestational age. Smokers and patients with white-coat hypertension were excluded. There were no differences between the two groups in age (p = 0.372), gender (p = 0.910), and body mass index (27.2 ± 4.6 vs. 25.9 ± 4.2 kg/m2 ; p = 0.409). Birth weight was significantly different (IUGR 2254.1 ± 536.4 vs. NBW 3402.9 ± 434.7 ; p < 0.001). Office BP was higher in the IUGR group (systolic 149 ± 12 vs. 157 ± 14 mmHg ; p = 0.047, and diastolic 99 ± 7 vs. 105 ± 6 mmHg ; p = 0.025). There were no differences in 24hour, daytime or nighttime BP values in ABPM neither in pulse pressure, BPL, heart rate or dipping status. However, in IUGR patients, we found increased overall 24h BP variability for both systolic (12.4 ± 2.7 vs. 15.2 ± 4.1 ; p = 0.008) and diastolic BP (11.6 ± 2.3 vs. 13.2 ± 2.5 ; p = 0.043). BP standard deviation scores were closely correlated with heart rate, especially during night (r = 0.58 ; p < 0.05). Preliminary data from an ongoing study on the effect of IUGR on BP in young adults were presented. In this highly selected group of patients, despite its small sample size, subtle abnormalities of BP control were observed. Increased BP variability observed in IUGR patients correlating closely with heart rate might be reflected in sympathetic hyperactivation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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