Naslov
Uric acid and circadian blood pressure pattern in previously untreated essential hypertensive patients with normal renal function

Autori
Laganović, Mario ; Pećin, Ivan ; Željković-Vrkić, Tajana ; Kuzmanić, Duško ; Pezo-Nikolić, Borka ; Kašner, Mario ; Vuković, Ivana ; Dika, Živka ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Central European Meeting on Hypertension ; u: Kidney & blood pressure research 32 (2009) (5) 309-333 ; Poster Presentations, 316-331 ; P-V5 / Cífková, R. ; Jelaković, Bojan - , 2009, 330-330

Skup
Central European Meeting on Hypertension (5 ; 2009)

Mjesto i datum
Zagreb, Hrvatska, 22.10.2009. - 25.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
uric acid; blood pressure; essential hypertension

Sažetak
The relation of uric acid on cardiovascular risk has been reported. Our aim was to investigate whether mildly elevated UA influences the circadian blood pressure pattern in patients with newly diagnosed essential hypertension (EH). In this study, 103 previously untreated EH patients (60 M, 43 F, mean age: 37 ± 9.1 years) with normal renal function were enrolled. BP was measured using a mercury sphygmomanometer and a Spacelabs 90207 device. Patients with white-coat hypertension were excluded. There were 39% of patients with UA levels in the high normal range (310–360 μmol/1) (HUA) and 61% with UA < 310 μmol/1 (NUA). Significantly more men than women had HUA (63.5% vs. 7.6% ; p < 0.001). Patients in the HUA group had increased BMI, waist circumference (WC), and fasting blood glucose (p < 0.05). There were no differences in age, eGFR, sodium excretion and BP values. We did not observe any differences in dipping status, BPL, BP variability or heart rate between HUA and NUA patients. UA positively correlates with BMI and WC (r = 0.39 and r = 0.45, respectively ; p < 0.05), as well with daytime and nighttime systolic BP (r = 0.28 and r = 0.26, respectively ; p < 0.05). In multiple regression analysis, only BMI showed a significant impact on dipping status (ß = –0.576 ; p = 0.05) while UA had an impact on systolic BP variability (ß = 0.569 ; p = 0.011). Our results support clustering of risk factors in patients with increased UA levels. Correlation of UA with BP values might be due to altered vasoconstriction present even in patients with HUA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA