Naslov
T-lymphoblastic Lymphoma with an Unusual t(8 ; 14)(q24 ; q11) : Case Report

Autori
Mandac, Inga ; Ostojić Kolonić, Slobodanka ; Vrhovac, Radovan ; Lasan-Trčić, Ružica ; Jakelić-Piteša, Jasminka ; Kardum-Skelin, Ika

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 1; 265-269

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, znanstveni

Ključne riječi
T-lymphoblastic lymphoma; cytogenetics; t(8; 14)(q24; q11)

Sažetak
Cytogenetic abnormalities seen at presentation of acute lymphoblastic leukemia or lymphoblastic lymphoma (ALL/ LBL) are associated with distinct clinical and hematologic disease entities. T-ALL/LBL are morphologically indistinguishable from those of B-ALL/LBL. An abnormal kariotype is found in 50–70% of cases of T-ALL/LBL. We present a 35-year old male patient with T-ALL/LBL and t(8 ; 14)(q24 ; q11.2). Our patient presented with B-symptoms, bulky mediastinal disease and CNS infiltration. Bone marrow was morphologically normal and cytogenetically without clonal aberrations. Cytological findings of the supraclavicular lymph node showed numerous CD3 positive (100%) and CD2 positive (88%) lymphoblasts, negative for CD34 and CD10. Flow cytometry of lymph node revealed T cell phenotype of im- mature cells: CD45+CD2+CD5+CD7+CD4+CD8+CD3cyt +CD3TdT+CD10-CD34-HLAD/DR-. Cytogenetic analysis of lymph node showed translocation t(1 ; 4)(p32 ; p12), t(8 ; 14)(q24 ; q11.2). Southern blot analysis of extracted DNA from the supraclavicular lymph node demonstrated clonal rearrangement of the T cell antigen receptor (TCR/J) gene (region Vb+Jb2). Based on these findings, diagnosis of T lymphoblastic non Hodgkin lymphoma was established. Cerebrospinal fluid analysis showed CNS infiltration with 49% lymphoblasts positive for CD4 and CD8. The disease progressed rapidly with poor response to therapy. T-ALL/LBL with an unusual t(8 ; 14)(q24 ; q11.2) is a very rare hematologic disorder with rapid disease progression and poor response to conventional therapy because of frequent central nervous system involvement and early relapses.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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