Naslov
Prognostic significance of plasma prostaglandin E concentration in patients with head and neck cancer

Autori
Klapan, Ivica ; Katić, Vladimir ; Čulo, Filip ; Ćuk, Višeslav

Izvornik
Journal of cancer research and clinical oncology (0171-5216) 118 (1992), 4; 308-313

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
head and neck tumours ; PGE ; prostaglandins ; squamous carcinoma

Sažetak
Plasma prostaglandin E (PGE) levels were determined by radioimmunoassay in 53 patients with various stages (II, III, and IV) of hypoharyngeal and laryngeal squamous cell carcinoma, in 12 non- cancer patients and in 10 healthy volunteers. The mean PGE concentration was somewhat higher in non- cancer patients (mean + SD = 34.6 + 5.37 pg/ml) than in healthy subjects (28.1 +4.96 pg/ml). In spite of a high data variability, the mean preoperative PGE levels in cancer patients were proportional to the stage of the disease and higher than in non-cancer patients (41.2 _ 19.7 pg/ml, 52.8 + 26.7 pg/ml and 82.0 + 34.9 pg/ml in stages II, III and IV respectively). The mean plasma PGE concentration significantly decreased for all tumour stages 15-30 days after surgical removal of the tumour, but rose again in some patients within 6-18 months after surgery. The incidence of tumour recurrences 6 and 18 months after surgery was significantly higher in patients with an increased preoperative PGE level (> 43.3 pg/ml) than in those patients with a PGE level within the normal range (< 43.3 pg/ml). The mortality was also higher in the former group, but the difference did not reach the level of significance. Similarly, the mean preoperative and most postoperative concentrations of PGE were significantly higher in patients in whom tumour recurred within 18 months than in tumour-free patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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