Pregled bibliografske jedinice broj: 458860
Pharmacokinetic Parameters of Statin Drugs Characterized by Reversed Phase High-performance Liquid Chromatohraphy
Pharmacokinetic Parameters of Statin Drugs Characterized by Reversed Phase High-performance Liquid Chromatohraphy // Analytical letters, 44 (2011), 6; 1009-1020 doi:10.1080/00032719.2010.511738 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 458860 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Pharmacokinetic Parameters of Statin Drugs Characterized by Reversed Phase High-performance Liquid Chromatohraphy
Autori
Mornar, Ana ; Damić, Miranda ; Nigović, Biljana
Izvornik
Analytical letters (0003-2719) 44
(2011), 6;
1009-1020
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lipophilicity; RP-HPLC; ADME; in silico approach
Sažetak
The aim of this study was to evaluate the usefulness of reversed-phase high performance liquid chromatography in building models that would allow prediction of ADME (absorption, distribution, metabolism and elimination) parameters of statin drugs in humans. The retention time of each drug was measured using C-18 and C-8 columns with an eluent acetonitrile-water. Furthermore, chromatographic data were compared with physicochemical properties and ADME data calculated by use of 17 different software programs. According to obtained results the calculated values correlate fairly well with chromatographic data which confirm the utility of liquid chromatographic technique for determination of pharmacokinetic parameters.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
006-0061117-1240 - Istraživanje novih metoda u analitici ljekovitih i bioaktivnih tvari (Nigović, Biljana, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
