Naslov
HFE mutations and transferrin C1/C2 polymorphism among Croatian patients with schizophrenia and schizoaffective disorder

Autori
Buretić-Tomljanović, Alena ; Vraneković, Jadranka ; Rubeša, Gordana ; Jonovska, Suzana ; Tomljanović, Draško ; Šendula-Jengić, Vesna ; Kapović, Miljenko ; Ristić, Smiljana

Izvornik
Molecular biology reports (0301-4851) 39 (2011), 3; 2253-2258

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia; schizoaffective disorder; hemochromatosis gene mutations; transferrin gene variant; age at disease onset
(schizophrenia; schizoaffective disorder; hemochromatosis gene mutations; transferrin gene variant)

Sažetak
The aim of this study was to investigate the possible influence of hemochromatosis gene mutations (HFE-C282Y and H63D) and transferrin gene C2 variant (TF-C2) on susceptibility to schizophrenia and schizoaffective disorder and/or age at first hospital admission. Genotyping was performed in 176 Croatian patients and 171 non-psychiatric Croatian controls using PCR-RFLP analyses. Regarding the H63D mutation, allele and genotype frequencies reached boundary statistical significance. Other allele and genotype distributions were not significantly different between two groups. We also analyzed age at first hospital admission as a continuous variable using the non-parametric Mann-Whitney U-test and Kruskal-Wallis test, and multiple regression analysis. The results of these tests were negative. We concluded that investigated HFE mutations and TF-C2 variant are not high-risk genetic variants for schizophrenia/schizoaffective disorder in our population. Also, our data do not support their impact on age at onset of the first psychotic symptoms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA