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Pregled bibliografske jedinice broj: 458715

High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.

Kos, Ivan; Benov, L.; Spasojević, Ivan; Rebouças, J.S., Batinić-Haberle, Ines
High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. // Journal of medicinal chemistry, 52 (2009), 23; 7868-7872 doi:10.1021/jm900576g (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 458715 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.

Autori
Kos, Ivan ; Benov, L. ; Spasojević, Ivan ; Rebouças, J.S., Batinić-Haberle, Ines

Izvornik
Journal of medicinal chemistry (0022-2623) 52 (2009), 23; 7868-7872

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lipophilicity; meta Mn(III) N-alkylpyridylporphyrin; superoxide dismutase mimics; antioxidant potency; Escherichia coli

Sažetak
Lipophilicity/bioavailibility of Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase (SOD) mimics has a major impact on their in vivo ability to suppress oxidative stress. Meta isomers are less potent SOD mimics than ortho analogues but are 10-fold more lipophilic and more planar. Enhanced lipophilicity contributes to their higher accumulation in cytosol of SOD-deficient Escherichia coli, compensating for their lower potency ; consequently, both isomers exert similar-to-identical protection of SOD-deficient E. coli. Thus meta isomers may be prospective therapeutics as are ortho porphyrins.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
006-0061247-0009 - Kinetika i mehanizam katalitičkog antioksidacijskog djelovanja Mn-porfirina (Budimir, Ana, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivan Kos (autor)

Poveznice na cjeloviti tekst rada:

doi pubs.acs.org pubs.acs.org

Citiraj ovu publikaciju:

Kos, Ivan; Benov, L.; Spasojević, Ivan; Rebouças, J.S., Batinić-Haberle, Ines
High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. // Journal of medicinal chemistry, 52 (2009), 23; 7868-7872 doi:10.1021/jm900576g (međunarodna recenzija, članak, znanstveni)
Kos, I., Benov, L., Spasojević, I. & Rebouças, J.S., Batinić-Haberle, Ines (2009) High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.. Journal of medicinal chemistry, 52 (23), 7868-7872 doi:10.1021/jm900576g.
@article{article, author = {Kos, Ivan and Benov, L. and Spasojevi\'{c}, Ivan}, year = {2009}, pages = {7868-7872}, DOI = {10.1021/jm900576g}, keywords = {lipophilicity, meta Mn(III) N-alkylpyridylporphyrin, superoxide dismutase mimics, antioxidant potency, Escherichia coli}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm900576g}, volume = {52}, number = {23}, issn = {0022-2623}, title = {High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.}, keyword = {lipophilicity, meta Mn(III) N-alkylpyridylporphyrin, superoxide dismutase mimics, antioxidant potency, Escherichia coli} }
@article{article, author = {Kos, Ivan and Benov, L. and Spasojevi\'{c}, Ivan}, year = {2009}, pages = {7868-7872}, DOI = {10.1021/jm900576g}, keywords = {lipophilicity, meta Mn(III) N-alkylpyridylporphyrin, superoxide dismutase mimics, antioxidant potency, Escherichia coli}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm900576g}, volume = {52}, number = {23}, issn = {0022-2623}, title = {High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.}, keyword = {lipophilicity, meta Mn(III) N-alkylpyridylporphyrin, superoxide dismutase mimics, antioxidant potency, Escherichia coli} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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