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Pregled bibliografske jedinice broj: 458681

BMP-6 and mesenchymal stem cell differentiation

Vukičević, Slobodan; Grgurević, Lovorka
BMP-6 and mesenchymal stem cell differentiation // Cytokine & growth factor reviews, 20 (2009), 5-6; 441-448 doi:10.1016/j.cytogfr.2009.10.020 (međunarodna recenzija, članak, znanstveni)

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Naslov
BMP-6 and mesenchymal stem cell differentiation

Autori
Vukičević, Slobodan ; Grgurević, Lovorka

Izvornik
Cytokine & growth factor reviews (1359-6101) 20 (2009), 5-6; 441-448

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone marrow-mesenchymal cells (BMSC); bone morphogenetic protein-6 (BMP-6); Bmp−/− mouse; iron metabolism; glucose regulation; diabetes; bone formation; coupling of bone formation to resorption; macrophage; synovial cells; cartilage repair; osteogenic transcription factors; BMP-6 receptors; BMP-6 structure

Sažetak
Bone morphogenetic protein-6 (BMP-6) is produced by bone marrow-mesenchymal (BMSC) and hematopoietic stem cells, which can differentiate into bone, cartilage, adipose, muscle, hematopoietic, synovial and other tissues. Bmp6-/- null mice have low hepcidin serum levels and an iron overload, resembling hereditary hemochromatosis, which may cause a reduced number of pancreatic beta-cells, increased serum glucose and diabetes. BMP-6 circulates in the normal human plasma and is produced by BMSC prior to differentiation into osteoblasts. Moreover, it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site. Due to unique structural, receptor binding and signaling characteristics much smaller amounts of BMP-6 than BMP-7 are needed in vivo to induce regeneration of bone defects in animals.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Bone Morphogenetic Proteins, Stem Cells and Regenerative Medicine ; A. Hari Reddi (Ed.)



POVEZANOST RADA

Projekti:
108-1080327-0320 - Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom (Vukičević, Slobodan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Slobodan Vukičević (autor)

Avatar Url Lovorka Grgurević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Vukičević, Slobodan; Grgurević, Lovorka
BMP-6 and mesenchymal stem cell differentiation // Cytokine & growth factor reviews, 20 (2009), 5-6; 441-448 doi:10.1016/j.cytogfr.2009.10.020 (međunarodna recenzija, članak, znanstveni)
Vukičević, S. & Grgurević, L. (2009) BMP-6 and mesenchymal stem cell differentiation. Cytokine & growth factor reviews, 20 (5-6), 441-448 doi:10.1016/j.cytogfr.2009.10.020.
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Grgurevi\'{c}, Lovorka}, year = {2009}, pages = {441-448}, DOI = {10.1016/j.cytogfr.2009.10.020}, keywords = {bone marrow-mesenchymal cells (BMSC), bone morphogenetic protein-6 (BMP-6), Bmp−/− mouse, iron metabolism, glucose regulation, diabetes, bone formation, coupling of bone formation to resorption, macrophage, synovial cells, cartilage repair, osteogenic transcription factors, BMP-6 receptors, BMP-6 structure}, journal = {Cytokine and growth factor reviews}, doi = {10.1016/j.cytogfr.2009.10.020}, volume = {20}, number = {5-6}, issn = {1359-6101}, title = {BMP-6 and mesenchymal stem cell differentiation}, keyword = {bone marrow-mesenchymal cells (BMSC), bone morphogenetic protein-6 (BMP-6), Bmp−/− mouse, iron metabolism, glucose regulation, diabetes, bone formation, coupling of bone formation to resorption, macrophage, synovial cells, cartilage repair, osteogenic transcription factors, BMP-6 receptors, BMP-6 structure} }
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Grgurevi\'{c}, Lovorka}, year = {2009}, pages = {441-448}, DOI = {10.1016/j.cytogfr.2009.10.020}, keywords = {bone marrow-mesenchymal cells (BMSC), bone morphogenetic protein-6 (BMP-6), Bmp−/− mouse, iron metabolism, glucose regulation, diabetes, bone formation, coupling of bone formation to resorption, macrophage, synovial cells, cartilage repair, osteogenic transcription factors, BMP-6 receptors, BMP-6 structure}, journal = {Cytokine and growth factor reviews}, doi = {10.1016/j.cytogfr.2009.10.020}, volume = {20}, number = {5-6}, issn = {1359-6101}, title = {BMP-6 and mesenchymal stem cell differentiation}, keyword = {bone marrow-mesenchymal cells (BMSC), bone morphogenetic protein-6 (BMP-6), Bmp−/− mouse, iron metabolism, glucose regulation, diabetes, bone formation, coupling of bone formation to resorption, macrophage, synovial cells, cartilage repair, osteogenic transcription factors, BMP-6 receptors, BMP-6 structure} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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