Naslov
The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice
(The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice)

Autori
Blagaić, Vladimir ; Houra, Karlo ; Turčić, Petra ; Štambuk, Nikola ; Konjevoda, Paško ; Boban-Blagaić, Alenka ; Kelava, Tomislav ; Kos, Marina ; Aralica, Gorana ; Čulo, Filip

Izvornik
Molecules (1420-3049) 15 (2010), 3; 1232-1245

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
melanocortins ; alpha-MSH ; beta-MSH ; gamma-MSH ; acetaminophen ; liver

Sažetak
Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory andcytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dosedependent manner.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA