Naslov
Gastroesophageal reflux and gastric hyperacidity in cystic fibrosis patients

Autori
Rožmanić, Vojko ; Tješić-Drinković, Dorian ; Banac, Srđan ; Ahel, Vladimir ; Tješić-Drinković, Duška ; Peršić, Mladen ; Votava-Raić, Ana

Izvornik
Paediatrics today (Tuzla) (1840-0914) 6 (2010), 1; 45-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cystic fibrosis ; gastroesophageal reflux ; gastric hyperacidity ; children ; lung function ; pH monitoring

Sažetak
Gastroesophageal reflux (GER) is increased in children with cystic fibrosis (CF). The role of gastric hyperacidity, which is common in CF patients with GER is not well characterized. Twenty-five CF children underwent 24 hour oesophageal pH monitoring. From each pH monitoring diurnal and nocturnal intervals were selected. In 10 patients 24-hour simultaneous oesophageal and gastric pH monitoring were performed.Thirteen of the 25 patients showed pathological GER. There were significantly more refluxes during diurnal pH monitoring. Nocturnal pH monitoring yielded significantly more refluxes longer than 5 minutes, longer episodes of refluxes and lower mean gastric and oesophageal pH. The method of choice for the diagnosis of gastroesophageal reflux in CF patients should be simultaneous oesophageal and gastric 24- hour monitoring including alert and sleep periods. Gastric acidity and reduced lung function facilitates reflux, which in turn might contribute to progression of pulmonary diseases as was seen in our patients

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA