Naslov
Sarcomatoid carcinoma of the ureter. A case report.

Autori
Mrčela, Milanka ; Blažičević, Valerija ; Galić, Josip ; Šimunović, Dalibor ; Koprolčec, Dalibor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Virchows Archiv Supplement 1 2009 / - , 2009, S226-S226

Skup
22nd European Congress of Pathology

Mjesto i datum
Firenca, Italija, 04.09.2009. - 09.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ureter; sarcomatoid carcinoma; carcinosarcoma; immunohistochemistry.

Sažetak
Introduction. Sarcomatoid carcinoma or sarcomatoid variant of urothelial carcinoma is the term that should be used for all biphasic malignant neoplasm's exhibiting morphologic and/or immunochistochemical evidence of epithelial and mesenchymal differentiation with or without heterologous elements. Case report. In this paper we described a case of biphasic malignant neoplasm of the ureter. The patient was 68-years-old woman admitted to the clinic because of painless hematuria, cystoscopically visible tumor protruding from right ureteral orifice, CT documented hydronephrosis and affunction of the right kidney. She underwent right nephroureteroctomy. The tumor consisted of four polypoid intraluminal masses that fulfill distal part of the ureter, and infiltrate ureteral wall. Microscopically, the majority of the tumor was composed of epithelial elements that show squamous or glandular differentiation, and only focal urothelial differentiation. Stroma was abundant fibro-mixoid or highly cellular composed of atypical mesenchymal spindle cells with high mitotic rate evidence. By immunohistochemistry, epithelial elements react with cytokeratin 10/13 and focally with cytokeratins 7, 8, 18 and 20. The epithelial elements were strongly NSE positive while Synaptophyisn and Chromogranin A showed only focal positivity. Atypical mesenchymal spindle cells showed immunoreactivity for Vimentin while Desmin and Actin were negative. The tumor infiltrated ureter wall and spread into periureteral fat tissue as well as into vascular spaces. Conclusion. Sarcomatoid carcinoma of the ureter is a rare aggressive neoplasm with unknown biology. Even terminology for biphasic urothelial neoplasm's is confused. Molecular studies suggest a monoclonal origin for both tumor components. In our case, epithelial component consisted of various epithelial cell types while stroma consisted of undifferentiated mesenchyma.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA