Naslov
Renal vascular resistance in autosomal dominant polycystic disease, Evaluation with color Doppler ultrasound

Autori
Brkljačić, Boris ; Sabljar-Martinović, Mirjana ; Putarek, Krešimir ; Soldo, Dragica ; Morović-Vergles, Jadranka ; Hauser, Mark

Izvornik
Acta Radiologica (0284-1851) 38 (1997), Nema; 840-846

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
kidney; cysts; autosomal dominant polycystic disease; vascular resistance; ultrasonography; duplex sonography.

Sažetak
The purpose of this study was to evaluate the performance of color duplex Doppler ultrasonography in the assessment of renal vascular resistance (RVR) by measuring resistive indices (RIs) and pulsatility indices (PIs) in patients with autosomal dominant polycystic kidney disease (ADPKD), and to correlate the measured values with renal function and the presence of arterial hypertension.Material and Methods: In 42 patients with ADPKD and 65 control subjects, RIs and PIs were measured by means of color duplex Doppler sonography and correlated with clinical and laboratory findings and with morphological abnormalities at B-mode ultra-sonography.Results: Mean RI in the control subjects was 0.59+/-0.03 (+/-SD) and in ihe patients 0.7+/-0.11, (p<0.01). Mean PI in the controls was 1.OO+/-0.11 and in the patients 1.69+/-0.21, (p<0.01). Elevated RIs and PIs heralded a progression of ADPKD. Doppler indices correlated significantly with renal function tests and morphological changes in the affected kidneys at ultrasound. Significantly higher RIs (p<0.01) and PIs (p<0.04) were measured in hypertensive ADPKD patients as compared to normotensive patients. Correlation of patient age and Doppler indices did not reach statistical significance.Conclusion: Doppler indices do refiect tlte increased RVR in patients with ADPKD and they correlate with renal function disturbance, with the development of systemic arterial hypertension, and with ultrasonographic abnormality of the kidney in these subjects.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Farmacija

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