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Pregled bibliografske jedinice broj: 454159

Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance

Chaudry, Rifat; Cikes, Maja; Karu, Tia; Hutchinson, Carmel; Ball, Sarah; Sutherland, George; Rosenthal, Mark; Bush, Andrew; Crowley, Suzanne
Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance // Thorax
London, Ujedinjeno Kraljevstvo, 2009. str. A19-A19 (predavanje, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 454159 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance

Autori
Chaudry, Rifat ; Cikes, Maja ; Karu, Tia ; Hutchinson, Carmel ; Ball, Sarah ; Sutherland, George ; Rosenthal, Mark ; Bush, Andrew ; Crowley, Suzanne

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Thorax / - , 2009, A19-A19

Skup
British Thoracic Society Winter Meeting 2009

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 02.12.2009. - 04.12.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Pulmonary hypertension; sickle cell disease; pulmonary vascular resistance

Sažetak
Pulmonary hypertension (PHT) is a common and serious complication in adults with sickle cell disease (SCD). Mortality is estimated to be 40% 40 months from diagnosis. Currently, age of onset and rate of progression are unknown. Our aim was to compare prevalence, severity and progression of PHT in paediatric SCD patients with age-, sex- and ethnically matched controls. We studied 50 patients with SCD, median age 14.0 years (range 10-18) and 50 healthy controls. Echocardiographic measurement of tricuspid regurgitant jet velocity (TRV) was used to estimate peak systolic pulmonary artery pressure (PAP). Pulmonary vascular resistance (PVREST) was estimated by dividing PAP by effective pulmonary blood flow (Qpeff) measured using acetylene rebreathing and respiratory mass spectrometry. 32% of patients (16/50) and 8% of control subjects (4/50) had echocardiographic evidence of PHT (TRV≥ 2.5 m/sec). However, when PAP (minus estimated left atrial pressure) was divided by Qpeff (L/min/m2) to calculate PVREST, SCD children actually had lower values than controls (p<0.05). Repeat echocardiography after a median of 20 months (range16-27.5) showed no overall change in PAP. In conclusion echocardiographic diagnosed PHT is common in children with SCD. However this appears to be secondary to raised cardiac output and not increased pulmonary vascular resistance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081875-1991 - Doppler miokarda u ranom otkrivanju i praćenju kardiovaskularnih bolesti (Šeparović-Hanževački, Jadranka, MZOS ) ( CroRIS)

Ustanove:
Klinički bolnički centar Zagreb

Profili:

Avatar Url Maja Čikeš (autor)

Citiraj ovu publikaciju:

Chaudry, Rifat; Cikes, Maja; Karu, Tia; Hutchinson, Carmel; Ball, Sarah; Sutherland, George; Rosenthal, Mark; Bush, Andrew; Crowley, Suzanne
Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance // Thorax
London, Ujedinjeno Kraljevstvo, 2009. str. A19-A19 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Chaudry, R., Cikes, M., Karu, T., Hutchinson, C., Ball, S., Sutherland, G., Rosenthal, M., Bush, A. & Crowley, S. (2009) Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance. U: Thorax.
@article{article, author = {Chaudry, Rifat and Cikes, Maja and Karu, Tia and Hutchinson, Carmel and Ball, Sarah and Sutherland, George and Rosenthal, Mark and Bush, Andrew and Crowley, Suzanne}, year = {2009}, pages = {A19-A19}, keywords = {Pulmonary hypertension, sickle cell disease, pulmonary vascular resistance}, title = {Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance}, keyword = {Pulmonary hypertension, sickle cell disease, pulmonary vascular resistance}, publisherplace = {London, Ujedinjeno Kraljevstvo} }
@article{article, author = {Chaudry, Rifat and Cikes, Maja and Karu, Tia and Hutchinson, Carmel and Ball, Sarah and Sutherland, George and Rosenthal, Mark and Bush, Andrew and Crowley, Suzanne}, year = {2009}, pages = {A19-A19}, keywords = {Pulmonary hypertension, sickle cell disease, pulmonary vascular resistance}, title = {Mild to moderate pulmonary hypertension in children with sickle cell disease is due to increased pulmonary blood flow secondary to anaemia rather than elevated pulmonary vascular resistance}, keyword = {Pulmonary hypertension, sickle cell disease, pulmonary vascular resistance}, publisherplace = {London, Ujedinjeno Kraljevstvo} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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