Naslov
Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined In vivo

Autori
Vučemilović, Ante ; Hadžija, Mirko ; Jukić, Ivan

Izvornik
Archives of Industrial Hygiene and Toxicology (0004-1254) 60 (2009), 2; 173-177

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bioactive potential ; MCC® ; nerve agent ; NOD mice ; sorption powder ; toxicity

Sažetak
Our Institute’s nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this in vivo study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC®) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC® was administered immediately after contamination. The results showed that decontamination with MCC® could achieve therapeutic efficacy corresponding to 3 x LD50 of percutaneous sarin and call for further research.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Kožna dekontaminacija živčanoga bojnog otrova sarina s apsorpcijskim pripravkom u uvjetima in vivo.

POVEZANOST RADA