Pregled bibliografske jedinice broj: 45045
Apolipoprotein E Polymorphism in the population of the Island of Krk
Apolipoprotein E Polymorphism in the population of the Island of Krk // 1st Alps Adria Meeting on Human Genetics / Stavljenić Rukavina, Ana (ur.).
Zagreb: Hrvatsko društvo za humanu genetiku, 2000. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 45045 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Apolipoprotein E Polymorphism in the population of the Island of Krk
Autori
Vitale, Ksenija ; Trbojević-Čepe, Marija ; Smolej Narančić, Nina
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
1st Alps Adria Meeting on Human Genetics
/ Stavljenić Rukavina, Ana - Zagreb : Hrvatsko društvo za humanu genetiku, 2000
Skup
1st Alps Adria Meeting on Human Genetics
Mjesto i datum
Brijuni, Hrvatska, 14.04.2000. - 15.04.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
apolipoprotein E; polymorphis; the island of Krk; population genetics; anthropology
Sažetak
Apolipoprotein E is a constituent of lipoprotein particles and thus a part of lipid metabolism system. Its gene is polymorphic with three alleles Apo E*2, E*3, E*4. Interest for apolipoprotein E isoformes stems from their connection with cardio-vascular and neurological disorders and use as population structure marker. As a part of eastern Adriatic population structure studies, Apo E polymorphism was investigated in the autochthonous, rural inhabitants of the island of Krk. The sample consisted of 192 males and 205 females from 7 villages with age span from 18-91 years. Collected sera were analyzed by isoelectricfocusing followed by immunoblotting using commercial specific antisera. The determined isoformes relative frequencies were 0.083 for E*2, 0.844 for E*3 and 0.073 for E*4. Compared with two other similar studies in Croatia, carried out in elderly and children, the frequency of Apo E*2 phenotype shows relatively higher values. When all three sets of data combined, variation of allele Apo E*2 and E*4 frequencies with age was revealed. Similar findings were reported for some populations from North America. Apo E allele frequencies reported for other European countries reveal decline of E*3 frequency and increase of E*4 frequency when going from south to north. Data from island of Krk fall to the position expected by this pattern.
Izvorni jezik
Engleski
Znanstvena područja
Etnologija i antropologija
