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Pregled bibliografske jedinice broj: 449303

Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Gjurašin, Miroslav; Miklić, Pavle; Župančić, Božidar; Perović, Darko; Žarković, Kamelija; Brčić, Luka; Kolenc, Danijela; Radić, Božo; Seiwerth, Sven; Sikirić, Predrag
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury // Regulatory peptides, 160 (2010), 1/3; 33-41 doi:10.1016/j.regpep.2009.11.005 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 449303 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Autori
Gjurašin, Miroslav ; Miklić, Pavle ; Župančić, Božidar ; Perović, Darko ; Žarković, Kamelija ; Brčić, Luka ; Kolenc, Danijela ; Radić, Božo ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Regulatory peptides (0167-0115) 160 (2010), 1/3; 33-41

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pentadecapeptide BPC 157 ; rat ; transected nerve

Sažetak
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 µg, 10 ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube. Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals). BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers, existence of epineural and perineural regeneration, uniform target orientation of regenerative fibers, and higher proportion of neural vs. connective tissue, all fascicles in each nerve showed increased diameter of myelinated fibers, thickness of myelin sheet, number of myelinated fibers per area and myelinated fibers as a percentage of the nerve transected area and the increased blood vessels presentation), electrophysiologically (increased motor action potentials), functionally (improved SFI), the autotomy absent. Thus, BPC 157 markedly improved rat sciatic nerve healing.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Žarković, Neven, MZOS ) ( CroRIS)
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Sikirić, Predrag, MZOS ) ( CroRIS)
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Žarković, Kamelija, MZOS ) ( CroRIS)
108-1080231-0324 - Promjene telencefaličke stijenke u bolesnika sa hidrocefalusom (Miklić, Pavle, MZOS ) ( CroRIS)
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Seiwerth, Sven, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Božidar Župančić (autor)

Avatar Url Sven Seiwerth (autor)

Avatar Url Miroslav Gjurašin (autor)

Avatar Url Darko Perović (autor)

Avatar Url Luka Brčić (autor)

Avatar Url Kamelija Žarković (autor)

Avatar Url Predrag Sikirić (autor)

Avatar Url Danijela Kolenc (autor)

Avatar Url Pavle Miklić (autor)

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Gjurašin, Miroslav; Miklić, Pavle; Župančić, Božidar; Perović, Darko; Žarković, Kamelija; Brčić, Luka; Kolenc, Danijela; Radić, Božo; Seiwerth, Sven; Sikirić, Predrag
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury // Regulatory peptides, 160 (2010), 1/3; 33-41 doi:10.1016/j.regpep.2009.11.005 (međunarodna recenzija, članak, znanstveni)
Gjurašin, M., Miklić, P., Župančić, B., Perović, D., Žarković, K., Brčić, L., Kolenc, D., Radić, B., Seiwerth, S. & Sikirić, P. (2010) Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Regulatory peptides, 160 (1/3), 33-41 doi:10.1016/j.regpep.2009.11.005.
@article{article, author = {Gjura\v{s}in, Miroslav and Mikli\'{c}, Pavle and \v{Z}upan\v{c}i\'{c}, Bo\v{z}idar and Perovi\'{c}, Darko and \v{Z}arkovi\'{c}, Kamelija and Br\v{c}i\'{c}, Luka and Kolenc, Danijela and Radi\'{c}, Bo\v{z}o and Seiwerth, Sven and Sikiri\'{c}, Predrag}, year = {2010}, pages = {33-41}, DOI = {10.1016/j.regpep.2009.11.005}, keywords = {pentadecapeptide BPC 157, rat, transected nerve}, journal = {Regulatory peptides}, doi = {10.1016/j.regpep.2009.11.005}, volume = {160}, number = {1/3}, issn = {0167-0115}, title = {Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury}, keyword = {pentadecapeptide BPC 157, rat, transected nerve} }
@article{article, author = {Gjura\v{s}in, Miroslav and Mikli\'{c}, Pavle and \v{Z}upan\v{c}i\'{c}, Bo\v{z}idar and Perovi\'{c}, Darko and \v{Z}arkovi\'{c}, Kamelija and Br\v{c}i\'{c}, Luka and Kolenc, Danijela and Radi\'{c}, Bo\v{z}o and Seiwerth, Sven and Sikiri\'{c}, Predrag}, year = {2010}, pages = {33-41}, DOI = {10.1016/j.regpep.2009.11.005}, keywords = {pentadecapeptide BPC 157, rat, transected nerve}, journal = {Regulatory peptides}, doi = {10.1016/j.regpep.2009.11.005}, volume = {160}, number = {1/3}, issn = {0167-0115}, title = {Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury}, keyword = {pentadecapeptide BPC 157, rat, transected nerve} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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