Naslov
HLA class I polymorphism in the Albanian population

Autori
Grubić, Zorana ; Brkljačić-Kerhin, Vesna ; Čečuk-Jeličić, Esma ; Kuci, Selim ; Kaštelan, Andrija

Izvornik
Collegium antropologicum (0350-6134) 24 (2000), 2; 303-307

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HLA; Albanian population

Sažetak
The HLA class I polymorphism was studied in a sample of the Albanian population. Ninety-three unrelated healthy Albanians were typed for HLA-A, -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with the highest frequencies were: HLA-A2 (34.4%), A3 (14.5%) and A1 (12.4%) ; B51 (19.3%), B35 (12.4%) and B18 (10.2%) ; Cw4 (16.2%), Cw7 (16.2%) and Cw6 (10.8%). The HLA haplotypes with high frequency in Albanians included A2-B51 (4.3%), A2-B18 (2.4%), A2-B35 (2.4%), Cw4-B35 (7.6%), and Cw7-B18 (6.5%), which are not significantly different from the other neighboring populations. Low frequency of HLA-A1-B8 haplotype (1.1%) is noted in the Albanian population. The frequency of HLA-B27 antigen (1.1%) is one of the lowest frequencies observed in Caucasians. Such results are important in studies of HLA-A1-B8, HLA-B27 and disease associations. These findings should be also useful in understanding the origin of Albanians, representing a base for future studies about HLA polymorphism in the Albanian population.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA