Naslov
Juvenile chronic arthritis is associated with a decreased activity of lectins that bind mannose and N-acetylgalactosamine

Autori
Lauc, Gordan ; Dumić, Jerka ; Flögel, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th Alps-Adria Congress of Clinical Chemistry and Laboratory Medicine Abstract Book / . - Opatija : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2000, P1/08-27

Skup
6th Alps-Adria Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Opatija, Hrvatska, 15.06.2000. - 17.06.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
juvenile rheumatoid arthritis; lectins; glycoprobe

Sažetak
Over a half of all known proteins contain covalently linked oligosaccharide structures that presumably perform some specific physiological functions. Due to the lack of adequate methods, until recently only little was known about the role of oligosaccharide structures of glycoconjugates, but in the recent years it was convincingly demonstrated that at least some of these structures are of utmost importance. One of the principal ways how oligosaccharides perform their functions is through interactions with their specific receptors named lectins. Recently we have developed glycoprobes, a novel set of compounds that enable direct measurement of lectin activity in complex biological samples. Using this method we have analyzed lectins that bind to mannose and N-acetylgalactosamine in sera of patients suffering from juvenile chronic arthritis. We have determined that juvenile chronic arthritis is associated with highly significant decrease in the activity of several specific lectins, while the activity of some other lectins did not change.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA