Naslov
Spatial Profiles of Correlation in Spike Timing to Broadband Noise Across Auditory Nerve Fibers

Autori
Kovacic, Damir ; Michelet, Pascal ; Joris, Philip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ABSTRACTS OF THE THIRTY-THIRD ANNUAL MIDWINTER RESEARCH MEETING - ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY / Santi, Peter A. - Gloucester (NJ) : Association for Research in Otolaryngology, 2010, 256-257

Skup
THE THIRTY-THIRD ANNUAL MIDWINTER RESEARCH MEETING OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Mjesto i datum
Anaheim (CA), Sjedinjene Američke Države, 06.02.2010. - 10.02.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
auditory neuroscience; cochlear implants

Sažetak
The cat auditory nerve (AN) contains ~50000 neurons innervating ~2500 inner hair cells across the cochlear basilar membrane. We are interested in the extent to which these neurons carry correlated temporal patterns, which depends on both the acoustic stimuli and intrinsic properties of the auditory periphery. Due to cochlear filtering, even Gaussian broadband noise – for which adjacent frequencies have random phase - can produce correlated responses in fibers originating from nearby cochlear positions. We studied the spatial profile and extent over which correlated responses to broadband noise are found in the AN. Neural responses to repeated presentations of a single token of broadband noise were obtained from all fibers encountered in a given nerve. Spike trains from each fiber (“reference fiber”) were compared with spike trains of all other fibers (“test fibers”) in order to obtain normalized same-stimulus cross-correlograms (SCC). As reported earlier (Joris et al., 2006), such SCCs show maxima at delays that depend on the distance between cochlear positions of the two fibers. We measured correlation in two ways: a) as the height of the largest peak of the SCC (“PH”) and b) as the SCC value at zero delay (“T0”). The observed spatial profiles show broad regions of correlation centered on the reference fiber. Using the PH metric, the half-widths of spatial profiles were large for apical cochlear regions and decreased towards the base. Using the T0 metric, half-widths were much smaller and increased towards the base, so that at the most basal locations half-widths were similar for PH and T0. The results indicate that, if the CNS has monaural delays available to compare timing across fibers of different CFs at different delays, the spatial bandwidth of correlation is much broader than when such delays are not available. Supported by fellowships to DK (Marie-Curie GA221755 & NSF Croatia) and PM (IWT SB-81346), and grants FWO (G.0633.07 & G.0714.09) and BOF (OT/05/57).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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