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Pregled bibliografske jedinice broj: 445697

Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells

Čimbora-Zovko, Tamara; Fritz, Gerhard; Mikac, Nevenka; Osmak, Maja
Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells // Cancer letters, 295 (2010), 2; 182-190 doi:10.1016/j.canlet.2010.02.025 (međunarodna recenzija, članak, znanstveni)

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Naslov
Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells

Autori
Čimbora-Zovko, Tamara ; Fritz, Gerhard ; Mikac, Nevenka ; Osmak, Maja

Izvornik
Cancer letters (0304-3835) 295 (2010), 2; 182-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cisplatin ; drug resistance ; Rho GTPases ; RhoB

Sažetak
Acquired resistance to cisplatin represents a major obstacle to an efficient chemotherapy. We found downregulation of RhoB expression in cisplatin-resistant tumor cell lines from different origin. In cisplatin-resistant laryngeal carcinoma subline overexpression of farnesylated or geranylgeranylated RhoB increased cisplatin-induced cell death, while silencing of RhoB expression diminished sensitivity of parental HEp-2 cells via decreased cellular accumulation of cisplatin. However, since RhoB silencing in additional tumor cell lines did not alter their sensitivity to cisplatin, we can assume that RhoB downregulation does not provide general protective role in cell response to cisplatin. Nevertheless, gene therapy involving restoration of RhoB expression might improve the efficiency of cisplatin treatment, especially in patients with laryngeal carcinoma that acquired resistance to this chemotherapeutic drug.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Osmak, Maja, MZOS ) ( CroRIS)
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Ambriović Ristov, Andreja, MZOS ) ( CroRIS)
098-0982934-2715 - Biogeokemija metala u sedimentacijskim sustavima i tlima Hrvatske (Kniewald, Goran, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Tamara Čimbora Zovko (autor)

Avatar Url Maja Osmak (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Čimbora-Zovko, Tamara; Fritz, Gerhard; Mikac, Nevenka; Osmak, Maja
Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells // Cancer letters, 295 (2010), 2; 182-190 doi:10.1016/j.canlet.2010.02.025 (međunarodna recenzija, članak, znanstveni)
Čimbora-Zovko, T., Fritz, G., Mikac, N. & Osmak, M. (2010) Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells. Cancer letters, 295 (2), 182-190 doi:10.1016/j.canlet.2010.02.025.
@article{article, author = {\v{C}imbora-Zovko, Tamara and Fritz, Gerhard and Mikac, Nevenka and Osmak, Maja}, year = {2010}, pages = {182-190}, DOI = {10.1016/j.canlet.2010.02.025}, keywords = {cisplatin, drug resistance, Rho GTPases, RhoB}, journal = {Cancer letters}, doi = {10.1016/j.canlet.2010.02.025}, volume = {295}, number = {2}, issn = {0304-3835}, title = {Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells}, keyword = {cisplatin, drug resistance, Rho GTPases, RhoB} }
@article{article, author = {\v{C}imbora-Zovko, Tamara and Fritz, Gerhard and Mikac, Nevenka and Osmak, Maja}, year = {2010}, pages = {182-190}, DOI = {10.1016/j.canlet.2010.02.025}, keywords = {cisplatin, drug resistance, Rho GTPases, RhoB}, journal = {Cancer letters}, doi = {10.1016/j.canlet.2010.02.025}, volume = {295}, number = {2}, issn = {0304-3835}, title = {Downregulation of RhoB GTPase confers resistance to cisplatin in human larygneal carcinoma cells}, keyword = {cisplatin, drug resistance, Rho GTPases, RhoB} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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