Pregled bibliografske jedinice broj: 443893
Effects of various cholinomimetic agents on passive avoidance behaviour in the nucleus basalis lesioned rats
Effects of various cholinomimetic agents on passive avoidance behaviour in the nucleus basalis lesioned rats // Iugoslavica physiologica et pharmacologica acta, 26 (1990), 1; 267-274 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 443893 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effects of various cholinomimetic agents on
passive avoidance behaviour in the nucleus basalis
lesioned rats
Autori
Simonić, Ante ; Župan, Gordana ; Domino, Edward F.
Izvornik
Iugoslavica physiologica et pharmacologica acta (0021-3225) 26
(1990), 1;
267-274
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
nucleus basalis lesion ; cholinomimetics ; passive avoidance
Sažetak
A hypocholinergic animal model of Alzheimer's disease was developed by producing bilateral electrolytic lesions of the nucleus basalis (NB) in rats. Brain lesioned rats demonstrated significant impairment of passive avoidance compared to control animals both drug naive, without lesions and sham-operated animals. The ACh precursor lecithin and the muscarinic agonist arecoline significantly improved passive avoidance in the NB lesioned rats. The AChE inhibitors physostigmine, galanthamine, and tetrahyidroaminoacridine were ineffective in reversing the memory deficits in the NB lesioned rats.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
