Pregled bibliografske jedinice broj: 443715
Separation, Characterization and Quantification of Atorvastatin and Related Impurities by Liquid Chromatography-Electrospray Ionization Mass Spectrometry
Separation, Characterization and Quantification of Atorvastatin and Related Impurities by Liquid Chromatography-Electrospray Ionization Mass Spectrometry // Analytical letters, 43 (2010), 18; 2859-2871 doi:10.1080/00032711003763624 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 443715 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Separation, Characterization and Quantification of Atorvastatin and Related Impurities by Liquid Chromatography-Electrospray Ionization Mass Spectrometry
Autori
Mornar, Ana ; Damić, Miranda ; Nigović, Biljana
Izvornik
Analytical letters (0003-2719) 43
(2010), 18;
2859-2871
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Atorvastatin; Electrospray ionization; Tandem mass spectrometry; Related impurities; Pharmaceuticals
Sažetak
A method coupling high-performance liquid chromatography with diode-array detector and electrospray ionization mass spectrometry (HPLC-DAD-ESI/MSn) has been developed for the separation and characterization of atorvastatin and its related impurities. The results obtained using positive ion mode showed some diagnostic fragments which are useful for the identification of atorvastatin related impurities in real samples. Quantitative analysis of drug impurities was performed in the multiple reaction monitoring mode. Quantitation limits for impurities were in the ranges 21.5-70.8 ng mL-1. The method was successfully applied to the drug purity evaluation and quantitative determination of atorvastatin related impurities in bulk drugs and pharmaceutical formulations.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Farmacija
POVEZANOST RADA
Projekti:
006-0061117-1240 - Istraživanje novih metoda u analitici ljekovitih i bioaktivnih tvari (Nigović, Biljana, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
