Naslov
Novel purine analogues as potential antiviral agents : synthetic, 1H and 13C NMR studies

Autori
Raić-Malić, Silvana ; Pongračić, Mario ; Vikić-Topić, Dražen ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
The tenth European Symposium on Organic Chemistry (10 ; 1997)

Mjesto i datum
Basel, Švicarska, 22.06.1997. - 27.06.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
purine analogues; antiviral agents; synthesis; 1H and 13C NMR spectroscopy

Sažetak
A large number of the open-chain sugar analogues of nucleoside have been made the object of intensive chemical and pharmacological investigation due to their potential activity as antiviral and anti-HIV agents. This investigation is concerned with the synthesis of the novel 6-(N-pyrrolyl)purine and adenine nucleoside analogues with acyclic side chains attached to the purine ring at N-9 and N-7 (Scheme). The site of alkylation was deduced on the basis of 1H and 13C NMR spectra by using analysis of chemical shifts, coupling constants and connectivities in NOESY and heteronuclear correlation spectra.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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