Naslov
The novel acyclic purine nucleoside analogues as potential antiviral agents : synthetic, NMR and X-ray crystal structure study

Autori
Raić, Silvana ; Pongračić, Mario ; Vorkapić-Furač, Jasna ; Vikić-Topić, Dražen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The eleventh Dubrovnik International Course and Conference on the Interfaces among Mathematics, Chemistry and Computer Science : abstracts / - , 1996

Skup
Dubrovnik International Course and Conference on the Interfaces among Mathematics, Chemistry and Computer Science (11 ; 1996)

Mjesto i datum
Dubrovnik, Hrvatska, 26.06.1996. - 01.07.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acyclic purine nucleoside analogues; antiviral agents; synthesis; NMR spectroscopy; x-ray crystallography

Sažetak
A large number of the open-chain sugar analogues of nucleoside have been made the object of intensive chemical and pharmacological investigation due to their potential activity as antiviral and anti-HIV agents. This investigation is concerned with the synthesis of the novel 6-(N-pyrrolyl)purine and adenine nucleoside analogues with acyclic side chains attached to the purine ring at N-9 and N-7 (Scheme). The site of alkylation was deduced on the basis of 1H and 13C NMR spectra by using analysis of chemical shifts, coupling constants and connectivities in NOESY and heteronuclear correlation spectra

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA