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Pregled bibliografske jedinice broj: 442295

Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin

Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin // Toxicology and applied pharmacology, 241 (2009), 3; 311-321 doi:10.1016/j.taap.2009.09.001 (međunarodna recenzija, članak, znanstveni)

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Naslov
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin

Autori
Domitrović, Robert ; Jakovac, Hrvoje ; Tomac, Jelena ; Šain, Ivana

Izvornik
Toxicology and applied pharmacology (0041-008X) 241 (2009), 3; 311-321

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
carbon tetrachloride; liver fibrosis; luteolin; α-smooth muscle actin; glial fibrillary acidic protein; matrix metalloproteinase; metallothionein

Sažetak
Hepatic fibrosis is effusive wound healing process in which excessive connective tissue builds up in the liver. Because specific treatments to stop progressive fibrosis of the liver are not available, we have investigated the effects of luteolin on carbon tetrachloride (CCl(4))-induced hepatic fibrosis. Male Balb/C mice were treated with CCl(4) (0.4 ml/kg) intraperitoneally (i.p.), twice a week for 6 weeks. Luteolin was administered i.p. once daily for next 2 weeks, in doses of 10, 25, and 50 mg/kg of body weight. The CCl(4) control group has been observed for spontaneous reversion of fibrosis. CCl(4)-intoxication increased serum aminotransferase and alkaline phosphatase levels and disturbed hepatic antioxidative status. Most of these parameters were spontaneously normalized in the CCl(4) control group, although the progression of liver fibrosis was observed histologically. Luteolin treatment has increased hepatic matrix metalloproteinase-9 levels and metallothionein (MT) I/II expression, eliminated fibrinous deposits and restored architecture of the liver in a dose-dependent manner. Concomitantly, the expression of glial fibrillary acidic protein and alpha-smooth muscle actin indicated deactivation of hepatic stellate cells. Our results suggest the therapeutic effects of luteolin on CCl(4)-induced liver fibrosis by promoting extracellular matrix degradation in the fibrotic liver tissue and the strong enhancement of hepatic regenerative capability, with MTs as a critical mediator of liver regeneration.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Robert Domitrović (autor)

Avatar Url Hrvoje Jakovac (autor)

Avatar Url Jelena Tomac (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Domitrović, Robert; Jakovac, Hrvoje; Tomac, Jelena; Šain, Ivana
Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin // Toxicology and applied pharmacology, 241 (2009), 3; 311-321 doi:10.1016/j.taap.2009.09.001 (međunarodna recenzija, članak, znanstveni)
Domitrović, R., Jakovac, H., Tomac, J. & Šain, I. (2009) Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Toxicology and applied pharmacology, 241 (3), 311-321 doi:10.1016/j.taap.2009.09.001.
@article{article, author = {Domitrovi\'{c}, Robert and Jakovac, Hrvoje and Tomac, Jelena and \v{S}ain, Ivana}, year = {2009}, pages = {311-321}, DOI = {10.1016/j.taap.2009.09.001}, keywords = {carbon tetrachloride, liver fibrosis, luteolin, α-smooth muscle actin, glial fibrillary acidic protein, matrix metalloproteinase, metallothionein}, journal = {Toxicology and applied pharmacology}, doi = {10.1016/j.taap.2009.09.001}, volume = {241}, number = {3}, issn = {0041-008X}, title = {Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin}, keyword = {carbon tetrachloride, liver fibrosis, luteolin, α-smooth muscle actin, glial fibrillary acidic protein, matrix metalloproteinase, metallothionein} }
@article{article, author = {Domitrovi\'{c}, Robert and Jakovac, Hrvoje and Tomac, Jelena and \v{S}ain, Ivana}, year = {2009}, pages = {311-321}, DOI = {10.1016/j.taap.2009.09.001}, keywords = {carbon tetrachloride, liver fibrosis, luteolin, α-smooth muscle actin, glial fibrillary acidic protein, matrix metalloproteinase, metallothionein}, journal = {Toxicology and applied pharmacology}, doi = {10.1016/j.taap.2009.09.001}, volume = {241}, number = {3}, issn = {0041-008X}, title = {Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin}, keyword = {carbon tetrachloride, liver fibrosis, luteolin, α-smooth muscle actin, glial fibrillary acidic protein, matrix metalloproteinase, metallothionein} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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