Naslov
Cognitive performance by humans during a smoked cocaine binge-abstinence cycle

Autori
Pace-Schott, Edward F. ; Stickgold, Robert ; Muzur, Amir ; Wigren, Pia E ; Ward, Amie S, Hart, Carl L ; Walker, Matthew ; Edgar, C. ; Hobson, J. Allan

Izvornik
American journal of drug and alcohol abuse (0095-2990) 31 (2005); 571-591

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cognition; cocaine; drug abuse

Sažetak
Five cocaine-dependent individuals completed a 22-day inpatient study of sleep and cognition. Following 3 days of drug-free baseline, participants underwent 3 days of twice-daily smoked cocaine base self-administration (6 50-mg doses, 14 minutes apart), followed by 15 days of abstinence. Each morning and afternoon, the CDR repeatable, multiple-version, computerized cognitive battery (whose stability following practice has been documented) was administered. During abstinence, performance deteriorated on vigilance tasks (especially reaction time) as well as on immediate and delayed verbal recognition tasks but not on working memory tasks. Declines were most evident in the afternoon. Data suggest that abstinence can unmask cognitive deficits induced by chronic cocaine use and circadian factors may mediate their severity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA