Naslov
Altered glycosphingolipid expression in mice lacking TNF receptor 1

Autori
Kovačić, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Izvornik
First Summer School of Croatian Institute for Brain Research / - , 1999

Skup
First Summer School of Croatian Institute for Brain Research

Mjesto i datum
Zagreb, Hrvatska, 05.07.1999. - 07.07.1999

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Sažetak
Expression of neutral glycosphingolipids (GSLs) and gangliosides in normal lymphoid tissues and cells has been studied mostly by biochemical and immunochemical analysis of lipid extracts separated by thin-layer chromatography. GSLs and gangliosides involved in GM1b-biosynthetic pathway were assigned to T lymphocytes, whereas B cell gangliosides and GSLs have been poorly characterized by former publications. We used specific polyclonal antibodies in immunohistology and flow cytometry to analyze the distribution of globotriaosylceramide (Gb3Cer), globoside (Gb4Cer), gangliotriaosylceramide (Gg3Cer), gangliotetraosylceramide (Gg4Cer), and gangliosides GM3 and GalNAc-GM1b in the mouse thymus, spleen, and lymph node from normal mice and mice homozygous for a gene knockout for TNFRp55.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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