Pregled bibliografske jedinice broj: 441402
Successfulness of two pharmacological strategies for conversions of recent-onset atrial fibrillation and perspectives of local drug delivery
Successfulness of two pharmacological strategies for conversions of recent-onset atrial fibrillation and perspectives of local drug delivery // 6th Global CardioVascular Clinical Trialists Forum Final Program & Abstracts Book / Zannad, Faiez ; Pitt, Bertram (ur.).
Pariz, 2009. str. 54-54 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 441402 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Successfulness of two pharmacological strategies for conversions of recent-onset atrial fibrillation and perspectives of local drug delivery
Autori
Miličević, Goran ; Strinić, Dean ; Gavranović, Željka ; Udiljak, Nikola ; Bakula, Miro
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
6th Global CardioVascular Clinical Trialists Forum Final Program & Abstracts Book
/ Zannad, Faiez ; Pitt, Bertram - Pariz, 2009, 54-54
Skup
6th Global CardioVascular Clinical Trialists Forum
Mjesto i datum
Pariz, Francuska, 03.12.2009. - 05.12.2009
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Atrial; Fibrillation; pharmacology; conversion; therapy
Sažetak
Introduction. Pharmacological conversion of recent-onset atrial fibrillation is important practical issue. Related to question of the ESC WG on Cardiovascular Pharmacology and Drug Therapy ‘how to best achieve cardioversion’, we analyzed successfulness of a single drug and sequential drug administration strategies. Furthermore, we tried to enhance the review with an idea on increasing the efficacy of conversion by local delivery of drugs. Methods. A systematic review of controlled trials, published in indexed journals, with antiarrhythmic drugs (of a class III, IC and IA, and atrial-selective) was performed. Eligible studies had to be randomized, controlled, parallel-designed, human trials that prove efficacy of pharmacological cardioversion of recent-onset atrial fibrillation. Results. High diversity in conversion rate of a single antiarrhythmic drug administration is shown, depending on drug dosage and time of its application. Sequential drug administration showed high success rate, but higher time consumption. Conclusion. Atrial-selective drugs have rapid onset of action, but sequential administration of older antiarrhythmic drugs shows excellent success rate. To enhance short-term success rate, local delivery of atrial-selective drugs may be needed. Possible models are proposed.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
219-0000000-3344 - Spektralna analiza varijabilnosti srčanog ritma u procjeni autonomnog disbalansa (Miličević, Goran, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
