Naslov
Single-nucleotide polymophisms in genes encoding toll-like receptor-2, -3, -4, and 9 in case-control study with breast cancer

Autori
Etokebe, Godfrey Essien ; Knežević, Jelena ; Petričević, Branka ; Pavelić, Jasminka ; Vrbanec, Damir ; Dembić, Zlatko

Izvornik
Genetic Testing and Molecular Biomarkers (1945-0265) 13 (2009), 6; 729-734

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast cancer; genetics; case-control; TLR2; TLR3; TLR4; TLR9

Sažetak
Genetic susceptibility to cancer is multifactorial, and it is known that impairment of the immune system could contribute to risk for getting cancer. Aim of the Study: Single-nucleotide polymorphisms (SNPs) of Toll-like receptor (TLR) 2, TLR3, TLR4, and TLR9 genes, which are important for innate immunity, were analyzed for the association with breast cancer. The SNPs comprised TLR2 (c.597T>C), TLR2 (c.1350T>C), TLR3 (c.1377C>T), TLR4 (c.896A>G), and TLR9 (c.1635A>G). The allelic and genotypic frequencies of these TLR SNPs were compared between patients (n¼130) and controls (n¼101) in a case–control study from Croatia. TLR SNPs were not significantly different. From the population genetics viewpoint, we found that a hypomorphic variant of TLR4 (p.Asp299Gly) allele has no specific allelic frequency (8.4%) in the Croatian population (n¼496) compared to other Caucasians (6.5–10%). These results suggest that polymorphisms in tested TLR genes are not likely to be associated with increased risk for developing breast cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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