Naslov
Thermodynamics of nanospheres encapsulated in virus capsids

Autori
Šiber, Antonio ; Zandi, Roya ; Podgornik, Rudolf

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Christmas Biophysics Workshop, Soft Matter meets Biological Physics / Georg Pabst - Graz, 2009, 14-14

Skup
4th Christmas Biophysics Workshop, Soft Matter meets Biological Physics

Mjesto i datum
Leibnitz, Austrija, 14.12.2009. - 15.12.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
virus; capsid; protein; electrostatics; assembly; gold

Sažetak
We investigate the thermodynamics of complexation of functionalized charged nano-spheres with viral proteins. The physics of this problem is governed by electrostatic interaction between the proteins and the nanosphere cores (screened by salt ions), but also by configurational degrees of freedom of the charged protein N-tails. We approach the problem by constructing an appropriate complexation free energy functional. On the basis of both numerical and analytical studies of this functional we construct the phase diagram for the assembly which contains the information on the assembled structures that appear in the thermodynamical equilibrium, depending on the size and surface charge density of the nanosphere cores. We show that both the nano-sphere core charge as well as its radius determine the size of the capsid that forms around the core.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA