Naslov
Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule?

Autori
Demirović, Alma ; Cesarec, Sanja ; Spajić, Borislav ; Tomas, Davor ; Bulimbašić, Stela ; Milošević, Milan ; Marušić, Zlatko ; Krušlin, Božo

Izvornik
Virchows Archiv (0945-6317) 456 (2010), 1; 85-89

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromophobe renal cell carcinoma; renal oncocytoma; capsule; morphometry

Sažetak
The most important differential diagnosis of chromophobe renal cell carcinoma is renal oncocytoma. Due to overlapping morphological characteristics of renal oncocytoma and chromophobe renal cell carcinoma, particularly its eosinophilic variant, making a correct diagnosis can be challenging. To date no data are available on the presence of the tumor fibrous capsule as a diagnostic feature in differentiating these tumors. The main purpose of this study was to establish the presence and compare the thickness of the tumor fibrous capsule between two tumor groups. A total of 37 tumors-18 cases of chromophobe renal cell carcinoma (3 eosinophilic and 15 classic) and 19 cases of renal oncocytoma-were analyzed. Four slides of each tumor stained with hematoxylin and eosin were first scanned at low-power magnification (X40) to assess the presence of the capsule. If present, capsule was measured in three different, thickest areas at higher magnification (X200). The mean value of capsule thickness was calculated and taken into consideration. Capsule was present in 12 (66.7%) cases of CRCCs and in only 2 (10.5%) cases of renal oncocytomas. Statistical analysis showed significant difference between the presence of fibrous capsule in these two observed tumor groups (P=0.001). Average thickness of capsule in CRCCs was 337.7 μm, and 115.4 μm in renal oncocytomas, but the median was not statistically significant (P=0.198). Studies with a larger number of cases are needed to conclude if this characteristic could be a low-cost, reliable microscopic feature in differentiating between chromophobe renal cell carcinoma and renal oncocytoma.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA