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Pregled bibliografske jedinice broj: 438015

Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives

Horvat, Štefica; Hameršak, Zdenko; Stipetić, Irena; Jolas, Thierry
Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives // European journal of medicinal chemistry, 45 (2010), 4; 1447-1452 doi:10.1016/j.ejmech.2009.12.049 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 438015 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives

Autori
Horvat, Štefica ; Hameršak, Zdenko ; Stipetić, Irena ; Jolas, Thierry

Izvornik
European journal of medicinal chemistry (0223-5234) 45 (2010), 4; 1447-1452

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pregabalin ; gabapentin ; binding affinity

Sažetak
A series of novel pregabalin derivatives were synthesized starting from N-protected pregabalin, different amino sugars, adamantylamine, serotonin and tryptamine. Gabapentin receptor binding assay study showed the one among them, the serotonin-pregabalin adduct 17, posseses a promissing activity (Ki =11 µM).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
098-0982933-2908 - Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost (Hameršak, Zdenko, MZOS ) ( CroRIS)
098-0982933-2936 - Kemijske preobrazbe prirodnih spojeva (Varga-Defterdarović, Lidija, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Štefica Horvat (autor)

Avatar Url Irena Dokli (autor)

Avatar Url Zdenko Hameršak (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Horvat, Štefica; Hameršak, Zdenko; Stipetić, Irena; Jolas, Thierry
Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives // European journal of medicinal chemistry, 45 (2010), 4; 1447-1452 doi:10.1016/j.ejmech.2009.12.049 (međunarodna recenzija, članak, znanstveni)
Horvat, Š., Hameršak, Z., Stipetić, I. & Jolas, T. (2010) Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives. European journal of medicinal chemistry, 45 (4), 1447-1452 doi:10.1016/j.ejmech.2009.12.049.
@article{article, author = {Horvat, \v{S}tefica and Hamer\v{s}ak, Zdenko and Stipeti\'{c}, Irena and Jolas, Thierry}, year = {2010}, pages = {1447-1452}, DOI = {10.1016/j.ejmech.2009.12.049}, keywords = {pregabalin, gabapentin, binding affinity}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2009.12.049}, volume = {45}, number = {4}, issn = {0223-5234}, title = {Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives}, keyword = {pregabalin, gabapentin, binding affinity} }
@article{article, author = {Horvat, \v{S}tefica and Hamer\v{s}ak, Zdenko and Stipeti\'{c}, Irena and Jolas, Thierry}, year = {2010}, pages = {1447-1452}, DOI = {10.1016/j.ejmech.2009.12.049}, keywords = {pregabalin, gabapentin, binding affinity}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2009.12.049}, volume = {45}, number = {4}, issn = {0223-5234}, title = {Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives}, keyword = {pregabalin, gabapentin, binding affinity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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