Naslov
Levamisole increases leukocyte count and immunoglobulin levels in young boars

Autori
Bilandžić, Nina ; Mitak, Mario ; Šimić, Branimir

Izvornik
Slovenian veterinary research (1580-4003) 47 (2010), 1; 13-19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
levamisole; leukocytes; immunoglobulins; boars

Sažetak
Levamisole has been used as an immunomodulator in the treatment of some diseases and conditions include parasitic invasions and immunocompromised conditions in domestic animals. The aim of the study is usage of levamisole to modulate the immune responsiveness in young boars in condition of intensive exploitation like handling using restraint. Therefore, hematological and immunological variables were assessed in Swedish Landrace boars treated with levamisole for three consecutive days. Levamisole treatment effected a significant increase in total leukocyte count immediately upon the last dosage (day 3, p<0.01), which persisted to days 4, 5 and 6 (p<0.01 to p<0.001). Also, the percentage of neutrophilic granulocytes increased significantly on days 5, 6 and 7 (p<0.001 and p<0.0001), whereas the percentage of eosinophil cells decreased significantly on days 7 and 11 after levamisole administration (p<0.01 and p<0.001). Lymphocyte, basophil and monocyte counts were unaffected by levamisole treatment. Serum IgG concentration was significantly elevated on days 5, 6, 7, 11 and 14 (p0.01 to p0.001, respectively), whereas IgA concentration showed a significant increase only on day 14 (p0.01) after levamisole administration. Levamisole treatment had no effect on serum levels of IgM. Cortisol levels remain unaffected throughout the period of observation. Levamisole treatment increased nonspecific cellular and humoral immunity in boars.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina, Biotehnologija

POVEZANOST RADA