Naslov
Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees

Autori
Vitart, Veronique ; Benčić, Goran ; Hayward, Caroline ; Herman Skunca, Jelena ; Huffman , Jennifer ; Campbell, Susan ; Bućan, Kajo ; Zgaga, Lina ; Kolčić, Ivana ; Polašek, Ozren ; Campbell, Harry ; Wright, Alan ; Vatavuk, Zoran ; Rudan, Igor

Izvornik
Investigative ophthalmology & visual science (0146-0404) 51 (2010), 2; 737-747

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oculometric traits; heritability; isolate population; stature

Sažetak
To assess the effects of body stature and years of education, in addition to age and sex, on 6 oculometric traits and to estimate the heritabilities of these quantitative traits in 2 Croatian cross-population studies. Adult subjects living on the 2 Croatian islands of Vis and Korcula were recruited for a large epidemiological and genetic study, which included eye biometry, keratometry and autorefraction. Effects and heritabilities were estimated using general linear mixed models for: axial length (AL), anterior chamber depth (ACD), corneal curvature (CC), corneal thickness (CT), lens thickness (LT), and spherical equivalent refraction (SER). Both cohorts have been genotyped using dense SNP arrays allowing to use kinship coefficients derived from genotypic data (realised kinship) rather than from pedigree information (expected kinship). Across cohorts, body mass index (BMI) did not consistently influence any of the ocular traits adjusted for age and/or sex, while height and years in education (YrEd) did, explaining up to an additional 5% of the variance (for CC). CT was the trait the least influenced by covariates. Estimated heritabilities, in respectively Vis and Korcula, were 84% and 52% for CC, 75% and 71% for CT, 37% and 32% for LT, 59% and 45% for ACD, 37% and 74% for AL, and 0% and 17% for SER. While heritabilities for CT and CC seem uniformly high across studies of Caucasian datasets, estimates for SER vary widely and were at the lower end of the spectrum of published observations in our study.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA