Pregled bibliografske jedinice broj: 435899
Human genome variation in health and in neuropsychiatric disorders
Human genome variation in health and in neuropsychiatric disorders // Psychiatria Danubina, 21 (2009), 4; 562-569 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 435899 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Human genome variation in health and in neuropsychiatric disorders
Autori
Buretić-Tomljanović, Alena ; Tomljanović, Draško
Izvornik
Psychiatria Danubina (0353-5053) 21
(2009), 4;
562-569
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
human genome variation; single nucleotide polymorphisms; copy number variation; noncoding genes; pseudogenes; transposable elements; neuropsychiatric disorders
Sažetak
Objectives: Variation in the human genome may explain genetic contributions to complex traits and common diseases. Findings: Until recently, single nucleotide polymorphisms were thought to be the most prevalent form of interindividual genetic variation. However, structural genomic rearrangements such as deletions, duplications, and inversions lead to variation in gene copy number and contribute even more to genomic diversity. Other sources of genomic variation include noncoding genes, pseudogenes, and mobile genetic elements (transposons). Conclusions: Genome dynamics, including changes in gene number and position as well as epigenetic modifications of coding and noncoding sequences, can affect regulation of gene expression and may contribute to the variability of complex phenotypes.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0982522-0369 - Genetika metabolizma fosfolipida u shizofreniji (Buretić-Tomljanović, Alena, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Alena Buretić-Tomljanović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)
- MEDLINE
- PsychINFO
- PsycLit (Psychological Abstracts)
- Social Services Abstracts
- Chemical Abstracts
- Cambridge Scientific Abstracts
- Science Citation Index Expanded
- Social Science Citation Index
- BioMedWorld.com
- Scopus.com
