Naslov
The variability and specificity of PAPP-A abd free β-hCG in the first trimester Down syndrome screening
(The variability and specificity of PAPP-A and free β-hCG in the first trimester Down syndrome screening)

Autori
Sabolović-Rudman, Senka ; Kulaš, Ivana ; Košec, Vesna ; Herman, Radoslav ; Tišlarić-Medenjak, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Perinatal Medicine - Abstracts 9th World Congress of Perinatal Medicine / - Berlin : Walter de Gruyter, 2009, 311-311

Skup
9th World Congress of Perinatal Medicine

Mjesto i datum
Berlin, Njemačka, 24.10.2009. - 28.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
first-trimester screening; Down syndrome; specificity of biochemical markers

Sažetak
Aim: To assess the specificity of biochemical markers: free β-hCG and PAPP-A during the first trimester of pregnancy and to determine the variability of maternal serum concentrations of studied markers between 10+3 and 13+6 weeks of gestation. Subjects: The study population comprised 2883 unaffected, singleton, non-diabetic and spontaneously conceived pregnancies. Pregnant women were separated in 4 groups, depending on the weeks of gestation when biochemical analyzes were performed. Methods: The concentrations of free β-hCG and PAPP-A in maternal serum were determined by solid-phase, enzyme-labeled chemiluminiscent immunometric assay (DPC-Immulite). Concentrations were converted to MoMs. according to centre-specific weighted regression median curves for free β-hCG and PAPP-A, obtained on daily median values for unaffected pregnancies. Results: There were no significant differences between sub-groups, according to the maternal age, maternal weight and the proportion of smokers. significant difference in log10 MoM values of free β-hCG (p<0, 05) was found between 11. and 12. weeks of gestation. Significant differences were ascertained for log10 MoM PAPP-A values between 11. and 12., as well as between 12. and 13. weeks of gestation (p<0, 05). False-positive rates of biochemical risk for trisomy 21 were 16, 1% before the 11th week, 12, 8% between weeks 11 and 11+6, 11, 9% between weeks 12 and 12+6, and 9, 9% after week 13. The differences in proportions were not statistically significant (χ2=0, 813, p=0, 37). Conclusion: Although MoM values of maternal serum free β-hCG and PAPP-A showed certain variations between 10th and 14th week of gestation, the impact on specificity of biochemical markers in study population was not satistically significant.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA